|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry.
|
19841890 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.
|
24117221 |
2014 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM.
|
28929635 |
2018 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The risk alleles G of rs3747517, rs2111485, rs13422767 and A of rs1990760 were observed more frequently in T1D group with P values and allelic odds ratio OR (95%CI) < 0.0001, 1.742 (1.428-2.126); 0.001, 1.336 (1.125-1.588); < 0.0001, 1.799 (1.416-2.285); 0.0005, 1.359 (1.144-1.616), respectively.
|
25515714 |
2015 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes.
|
17535987 |
2007 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 10 SNPs genotyped for the 2q region, four SNPs located within the IFIH1 gene or at the 5' region of IFIH1 showed significant association with T1D in the Georgia population [odds ratio (OR) = 1.7-1.9] with the best P-value found at SNP rs1990760 (P = 8 x 10(-8) and OR = 1.9).
|
18927125 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D.
|
26782418 |
2015 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes.
|
17442111 |
2007 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD).
|
19961590 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D.
|
28000722 |
2016 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus.
|
20694011 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients.
|
24386202 |
2013 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation.
|
19324880 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant.
|
20644636 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23).
|
19956106 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
|
23144876 |
2012 |
|
rs35667974
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To establish if these SNPs were also involved in MS susceptibility, we chose to examine the non-synonymous SNP rs35667974/Ile923Val which displayed the strongest effect in T1D and was also shown to lead to a loss of IFIH1 function in an in vitro study.
|
20116863 |
2010 |
|
rs35667974
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In this study, we showed a significant association of two rare IFIH1 variants, rs35744605 (E627X) and rs35667974 (I923V), with decreased risk of type 1 diabetes (T1D) in a Russian population (for the allele X627, odds ratio [OR] = 0.39, 95% confidence interval [95% CI] = 0.22-0.69, p = 0.0015; for the allele V923, OR = 0.45, 95% CI, 0.30-0.66, p = 5.4 × 10(-5)).
|
20736039 |
2010 |
|
rs3747517
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We conducted a case-control study, enrolling 173 T1D patients and 191 healthy controls from northeastern Brazil, to assess the distribution of the rs7574865 and rs3024839 SNPs in STAT4 and the rs3747517 and rs1990760 SNPs in IFIH1 in T1D and APSIII patients.
|
26782418 |
2015 |
|
rs3747517
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
rs3747517
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
|
rs35744605
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in the IFIH1 (common rs1990760 and four rare rs35667974, rs35337543, rs35744605, rs35732034) have been convincingly associated with type 1 diabetes.
|
23144876 |
2012 |
|
rs35744605
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we showed a significant association of two rare IFIH1 variants, rs35744605 (E627X) and rs35667974 (I923V), with decreased risk of type 1 diabetes (T1D) in a Russian population (for the allele X627, odds ratio [OR] = 0.39, 95% confidence interval [95% CI] = 0.22-0.69, p = 0.0015; for the allele V923, OR = 0.45, 95% CI, 0.30-0.66, p = 5.4 × 10(-5)).
|
20736039 |
2010 |