|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes.
|
17442111 |
2007 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes.
|
17535987 |
2007 |
|
rs1990760
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
rs1990760
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 10 SNPs genotyped for the 2q region, four SNPs located within the IFIH1 gene or at the 5' region of IFIH1 showed significant association with T1D in the Georgia population [odds ratio (OR) = 1.7-1.9] with the best P-value found at SNP rs1990760 (P = 8 x 10(-8) and OR = 1.9).
|
18927125 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation.
|
19324880 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry.
|
19841890 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23).
|
19956106 |
2009 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD).
|
19961590 |
2009 |
|
rs35667974
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To establish if these SNPs were also involved in MS susceptibility, we chose to examine the non-synonymous SNP rs35667974/Ile923Val which displayed the strongest effect in T1D and was also shown to lead to a loss of IFIH1 function in an in vitro study.
|
20116863 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant.
|
20644636 |
2010 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus.
|
20694011 |
2010 |
|
rs35667974
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In this study, we showed a significant association of two rare IFIH1 variants, rs35744605 (E627X) and rs35667974 (I923V), with decreased risk of type 1 diabetes (T1D) in a Russian population (for the allele X627, odds ratio [OR] = 0.39, 95% confidence interval [95% CI] = 0.22-0.69, p = 0.0015; for the allele V923, OR = 0.45, 95% CI, 0.30-0.66, p = 5.4 × 10(-5)).
|
20736039 |
2010 |
|
rs35744605
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we showed a significant association of two rare IFIH1 variants, rs35744605 (E627X) and rs35667974 (I923V), with decreased risk of type 1 diabetes (T1D) in a Russian population (for the allele X627, odds ratio [OR] = 0.39, 95% confidence interval [95% CI] = 0.22-0.69, p = 0.0015; for the allele V923, OR = 0.45, 95% CI, 0.30-0.66, p = 5.4 × 10(-5)).
|
20736039 |
2010 |
|
rs1990760
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
rs3747517
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
|
23144876 |
2012 |
|
rs35744605
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in the IFIH1 (common rs1990760 and four rare rs35667974, rs35337543, rs35744605, rs35732034) have been convincingly associated with type 1 diabetes.
|
23144876 |
2012 |
|
rs35732034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in the IFIH1 (common rs1990760 and four rare rs35667974, rs35337543, rs35744605, rs35732034) have been convincingly associated with type 1 diabetes.
|
23144876 |
2012 |
|
rs6432714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs6432714, a tag-SNP that represents part of helicase domain of IF1H1 protein showed a trend of association only with T1D development (P>0.025 after Bonferroni adjustment) in log-additive model (OR=1.45, P=0.0365, power=0.99), indicating that helicase domain of IFIH1 protein could be associated with the susceptibility to T1D.
|
23246693 |
2013 |
|
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |