rs1990760
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry.
|
19841890 |
2010 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.
|
24117221 |
2014 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM.
|
28929635 |
2018 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
rs1990760
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The risk alleles G of rs3747517, rs2111485, rs13422767 and A of rs1990760 were observed more frequently in T1D group with P values and allelic odds ratio OR (95%CI) < 0.0001, 1.742 (1.428-2.126); 0.001, 1.336 (1.125-1.588); < 0.0001, 1.799 (1.416-2.285); 0.0005, 1.359 (1.144-1.616), respectively.
|
25515714 |
2015 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes.
|
17535987 |
2007 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 10 SNPs genotyped for the 2q region, four SNPs located within the IFIH1 gene or at the 5' region of IFIH1 showed significant association with T1D in the Georgia population [odds ratio (OR) = 1.7-1.9] with the best P-value found at SNP rs1990760 (P = 8 x 10(-8) and OR = 1.9).
|
18927125 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D.
|
26782418 |
2015 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes.
|
17442111 |
2007 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD).
|
19961590 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D.
|
28000722 |
2016 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus.
|
20694011 |
2010 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients.
|
24386202 |
2013 |
rs1990760
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation.
|
19324880 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant.
|
20644636 |
2010 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23).
|
19956106 |
2009 |
rs1990760
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
|
23144876 |
2012 |
rs35667974
|
|
|
0.720 |
GeneticVariation |
BEFREE |
To establish if these SNPs were also involved in MS susceptibility, we chose to examine the non-synonymous SNP rs35667974/Ile923Val which displayed the strongest effect in T1D and was also shown to lead to a loss of IFIH1 function in an in vitro study.
|
20116863 |
2010 |