|
rs1136545
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The additional five SNPs revealed that rs7607888 (P = 2.03 × 10<sup>-7</sup>), rs55981318 (P = 0.018), and rs1136545 (P = 1.93 × 10<sup>-9</sup>) were also associated with T1D.
|
29204916 |
2018 |
|
rs143383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analyses based on disease type showed a significant association between the GDF5 rs143383 polymorphism and increased risk of IDD and OA under all genetic models studied.
|
30217184 |
2018 |
|
rs1437184398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report a novel recessive GPT2 stop mutation p.Gln24* causing a complex IDD phenotype in a homozygous state in 5 patients from 2 consanguineous Arab families.
|
29882329 |
2018 |
|
rs147846074
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic variant in the SAND domain of autoimmune regulator (AIRE), R247C, was identified in a patient with type I diabetes mellitus (T1DM) and his mother with rheumatoid arthritis.
|
29129473 |
2018 |
|
rs1893592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This reduction in UBASH3A, as a consequence of the minor allele at rs1893592</span>, resulted in increased secretion of IL-2, a key cytokine that is required for T-cell activation and function but is deficient in some T1D subjects.
|
29491471 |
2018 |
|
rs1902491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
|
30531682 |
2018 |
|
rs199946797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a recent sequencing study, an individual with juvenile-onset diabetes was observed to be homozygous for a rare missense variant (c.1672C>T, p.R558C) in the WFS1 gene.
|
30014265 |
2018 |
|
rs4506565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied TrialNet participants with newly diagnosed autoimmune type 1 diabetes with available <i>TCF7L2</i> rs4506565 and rs7901695 SNP data (<i>n</i> = 810; median age 13.6 years; range 3.3-58.6).
|
29025879 |
2018 |
|
rs4673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed a strong association of the CYBA polymorphism rs4673 with DPN in Slovak children and adolescents with T1D.
|
29924645 |
2018 |
|
rs4865047
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
|
30531682 |
2018 |
|
rs55981318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The additional five SNPs revealed that rs7607888 (P = 2.03 × 10<sup>-7</sup>), rs55981318 (P = 0.018), and rs1136545 (P = 1.93 × 10<sup>-9</sup>) were also associated with T1D.
|
29204916 |
2018 |
|
rs61734651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in COL9A3 gene sequence, leading to an Arg103Trp substitution in its 3 chain (the Trp3 allele at rs61734651 site), respectively, have been found to be connected with IDD occurrence in several studies.
|
30342505 |
2018 |
|
rs6422747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G allele in both SNPs was associated with a higher risk of IDD.The 2 SNPs (rs6422747 and rs6422748) in the THBS2 gene were associated with susceptibility of IDD but not severity of IDD in a Chinese Han population.
|
29480856 |
2018 |
|
rs6422748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G allele in both SNPs was associated with a higher risk of IDD.The 2 SNPs (rs6422747 and rs6422748) in the THBS2 gene were associated with susceptibility of IDD but not severity of IDD in a Chinese Han population.
|
29480856 |
2018 |
|
rs72975913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although these SNPs were not associated with type 1 diabetes overall (p > 0.001), the SNP most associated with AAD, rs72975913, was associated with susceptibility to type 1 diabetes in those individuals diagnosed at less than 5 years old (p = 2.3 × 10<sup>-9</sup>).
|
28983737 |
2018 |
|
rs75352297
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The established T1D SNPs rs1159465 (near IL2RA) and rs75352297 (near CCR2 and CCR3) were positively associated with IL-2Rα and CCL4, respectively (P < .01).
|
29266506 |
2018 |
|
rs7607888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The additional five SNPs revealed that rs7607888 (P = 2.03 × 10<sup>-7</sup>), rs55981318 (P = 0.018), and rs1136545 (P = 1.93 × 10<sup>-9</sup>) were also associated with T1D.
|
29204916 |
2018 |
|
rs763110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of FASL-844C/T (rs763110) polymorphism was statistically associated with decreased IDD risk under all genetic models (allele model: OR = 0.68, 95% CI 0.59-0.80, P = 0.000; homozygote model: OR = 0.35, 95% CI 0.25-0.53, P = 0.000; dominant model: OR = 0.38, 95% CI 0.25-0.58, P = 0.000; recessive model: OR = 0.69, 95% CI 0.58-0.84, P = 0.000).
|
29652777 |
2018 |
|
rs12512631
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations between serum 25OHD concentration and 2 SNPs, one in the vitamin D receptor (VDR) gene (rs4516035) and one in the group-specific component (GC) gene (rs12512631), were stronger during pregnancy in mothers whose children later developed type 1 diabetes than in mothers whose children did not (pinteraction = 0.03, 0.02, respectively).
|
28976992 |
2017 |
|
rs17583959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When haplotypes were constructed between CREM polymorphisms (rs1148247, rs17583959, rs2384352), AGA haplotype (H2) was significantly over-transmitted from parents to affected offspring (Z score=2.988; P=0.002) and may confer a risk for T1D disease.
|
27840176 |
2017 |
|
rs1950942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, we found that the SNP with the highest association with T1D susceptibility and IgG autoantibody reactivity (rs1950942) was also associated with anti-GAD IgM reactivity in T1D patients (P = 5.98E-03) and in non-affected parents (P = 4.17E-03).
|
28534223 |
2017 |
|
rs2384352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When haplotypes were constructed between CREM polymorphisms (rs1148247, rs17583959, rs2384352), AGA haplotype (H2) was significantly over-transmitted from parents to affected offspring (Z score=2.988; P=0.002) and may confer a risk for T1D disease.
|
27840176 |
2017 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MiR-146a rs2910164 and miR-155 rs767649 polymorphisms were associated with protection for T1DM.
|
28101643 |
2017 |
|
rs4613763
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found one allele on chromosome 5, rs4613763 mapping to a Prostaglandin Receptor EP4 (PTGER4) to reach statistical significance (P = .0067), in determining a larger proportion of T1DM patients with a detectable honeymoon phase.
|
27503178 |
2017 |
|
rs4622308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus.
|
28494655 |
2017 |