|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We aimed to evaluate the effect of four common variants (rs2237892, rs2283228, rs2237895, and rs2237897) in KCNQ1 on susceptibility of type 2 diabetes (T2D) by performing a case-control study as well as a comprehensive meta-analysis.
|
23786590 |
2013 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs2237892
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans.
|
24145053 |
2013 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNQ1 rs2237892 C→T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 15,736 patients.
|
24373634 |
2014 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs5215, rs10811661, and rs2237892 were in significant association with T2DM, and hazard ratios per risk allele score increase were 1.11 (95% confidence intervals: 1.06-1.17), 1.09 (1.01-1.05), 1.04 (1.02-1.07) with GPS-3, GPS-18, GPS-36, respectively.
|
26240488 |
2015 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C allele of rs2237892 variant contributed to susceptibility to T2DM (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.20-1.75).
|
26678516 |
2015 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The main anthropometric and biochemical parameters did not correlate with the rs2237892 or rs2237895 SNPs in the T2DM group (P > 0.05).
|
27323013 |
2016 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Haploview analysis showed that the ACC (rs151290, rs2237892 and rs2237895) haplotype is the most significant risk allele combination for CVD, while CCA is the most significant risk haplotype for co-morbidity with T2D.
|
28863213 |
2019 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs2237892
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of the present pilot study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
|
29520783 |
2018 |
|
rs2237892
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |