|
rs10498210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRS1- rs10498210 G/A and CCR5-59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan.
|
30884193 |
2019 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene.
|
16877540 |
2006 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the IRS-1 Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or Type 2 diabetes in obese persons.
|
15209769 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings revealed that IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group.
|
22994406 |
2012 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Gly9</span>72Arg polymorphism does not play an important role in the pathogenesis of NIDDM in Japanese patients.
|
7673430 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes.
|
12213887 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in the IRS genes have been identified, but only the Gly-->Arg972 substitution of IRS-1, interacting with environmental factors, seems to have a pathogenic role in the development of type 2 diabetes.
|
11641236 |
2001 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes.
|
12588284 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15127203 |
2004 |
|
rs13431554
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs13431554 in the IRS-1 gene was associated with a hyperreactive platelet phenotype in the CAD patients with T2DM.
|
27005817 |
2016 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.
|
24071662 |
2013 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type 2 diabetes and insulin resistance.
|
15590636 |
2005 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa.
|
24447396 |
2014 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed a significant difference in the genotype distribution and allele frequency between the T2DM cases and controls for single nucleotide polymorphism (SNP) rs1801278 (OR 17.61, 95% CI 8.06-38.4, p < 0.001).
|
31446532 |
2019 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1.
|
11978638 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian.
|
26582067 |
2016 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms in a large and ethnically homogeneous sample that IRS1 G972R polymorphism is associated with failure to OAD among patients with T2D.
|
24947357 |
2014 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.
|
9589236 |
1998 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |