|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
|
25165692 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 rs5219 is not independently associated with T2D in South-Indian population and our meta-analysis suggests that KCNJ11 polymorphism (rs5219) is associated with risk of T2D in East Asian population and global population but this outcome could not be replicated in South Asian sub groups.
|
25247988 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes.
|
26315042 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study showed that rs5219 polymorphism of the KCNJ11 gene is an important risk factor for type 2 diabetes mellitus in a sample of the Syrian population.
|
31195986 |
2019 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The KCNJ11 E23K and ABCC8 exon 31 variants contribute to susceptibility to T2D diabetes, glucose intolerance and altered insulin secretion in a Russian population.
|
18758683 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was a believable evidence to verify that rs5219 variation was associated with T2DM.
|
29685723 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Four type 2 diabetes SNPs were associated with colorectal cancer risk: rs7578597 (THADA), rs864745 (JAZF1), rs5219 (KCNJ11) and rs7961581 (TSPAN8, LGR5).
|
21602532 |
2011 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.
|
15797964 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
They also aid our understanding of how the Kir6.2-E23K variant predisposes to type 2 diabetes.
|
27118464 |
2016 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These data suggest that the E23K variant in KCNJ11 may influence the variability in the response of patients to sulfonylureas, thus representing an example of pharmacogenetics in type 2 diabetes.
|
16595597 |
2006 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
|
17259403 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth.
|
28449408 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 E23K polymorphism was associated with type 2 diabetes in genetic association studies.
|
22385882 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs5219 was not associated with type 2 diabetes in the Chinese Han population.
|
24065655 |
2013 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
|
23298195 |
2013 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
|
22209866 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The common KCNJ11 E23K gene variant, but not the ABCC8 exon 16 or exon 18 variant, was consistently associated with Type 2 diabetes.
|
15842514 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes.
|
17994213 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes.
|
29893194 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility.
|
17823772 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
|
20054294 |
2010 |