|
rs1056892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional CBR3 V244M polymorphism may have an impact on the risk of anthracycline-related CHF among childhood cancer survivors by modulating the intracardiac formation of cardiotoxic anthracycline alcohol metabolites.
|
18457324 |
2008 |
|
rs1061622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
rs10757274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
rs10757278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-allele of both SNPs predicted incident stroke in crude additive models [rs2383207 hazard ratios = 1.25 (95% CI = 1.02-1.53), P = 0.04 and rs10757278 hazard ratios = 1.34 (95% CI = 1.09-1.65), P = 0.006], as well as after adjustment for classical cardiovascular risk factors and after additional adjustment for prevalent and incident coronary events, atrial fibrillation, ischemic heart disease and congestive heart failure.
|
19293724 |
2009 |
|
rs10927887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Individual genotyping of rs10927887 in the two study populations and a third independent heart failure cohort (combined n = 5,489) revealed an additive allele effect on heart failure risk that is independent of age, sex, and prior hypertension (odds ratio = 1.27 per allele copy; P = 8.3 × 10(-7)).
|
21248228 |
2011 |
|
rs10927887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.
|
23850580 |
2013 |
|
rs10932374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-G-C-C-T haplotype of rs10932374</span>-rs13003941-rs1595064-rs1595065-rs3748960 in the ErbB4 gene increased the risk of heart failure (odd ratio 1.35, 95% confidence interval [CI] 1.06-1.70; P = .014).
|
26844763 |
2016 |
|
rs111033560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strikingly, both individuals homozygous for L39stop developed dilated cardiomyopathy and heart failure, requiring cardiac transplantation at ages 16 and 27.
|
12639993 |
2003 |
|
rs1136201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This review found that HER2 rs1136201 can have the potential in predicting trastuzumab-related heart failure.
|
30594345 |
2019 |
|
rs1137101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subanalyses according to CHF etiology the LEPR Gln223Arg showed an independent prediction role for NYHA IV in IHD patients (P = 0.0001, OR = 2.50, 95% CI = 1.69-3.82) and both for NYHA IV(P = 0.007, OR = 2.04, 95% CI = 1.20-3.84) and LVEF (P = 0.004, OR = 11.87, 95% CI = 2.08-55.6) in DCMP patients.
|
19337797 |
2009 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distributions of GSTM1 and GSTT1 deletion polymorphisms and C677T variant of MTHFR were examined in a sample of 94 hypertensive patients with congestive heart failure and 207 healthy unrelated Portuguese individuals using PCR techniques.
|
17182005 |
2007 |
|
rs121918080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis.
|
10834537 |
2000 |
|
rs121918090
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe two Italian first cousins with familial amyloidotic polyneuropathy associated with transthyretin variant consisting of the substitution of alanine for glycine at codon 47 (TTR Ala-47), from a family with a history of cardiac failure.
|
10677864 |
2000 |
|
rs121918598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Development of HF was not aggravated by increased SR Ca<sup>2+</sup> leak due to RyR2 mutation (R2474S) in volume overload, an SR Ca<sup>2+</sup> leak-independent HF model.
|
30209242 |
2018 |
|
rs1222174664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distributions of GSTM1 and GSTT1 deletion polymorphisms and C677T variant of MTHFR were examined in a sample of 94 hypertensive patients with congestive heart failure and 207 healthy unrelated Portuguese individuals using PCR techniques.
|
17182005 |
2007 |
|
rs1249958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the human G109E inhibitor-1 variant impairs SR Ca-cycling and promotes arrhythmogenesis under stress conditions, which may present an additional insult in the compromised function of heart failure carriers.
|
26455482 |
2015 |
|
rs1253810269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This pharmacogenetic substudy of the prospective, double-blind, randomized CIBIS-ELD trial determined the impact of the β1-adrenoceptor Arg189Gly polymorphism on heart-rate responses to bisoprolol or carvedilol in elderly patients with heart failure (421 with sinus rhythm, 107 with atrial fibrillation).
|
22617224 |
2012 |
|
rs12564445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The hs-cTnT-associated single-nucleotide polymorphisms were not associated with coronary heart disease in a large case-control study, but rs12564445 was significantly associated with incident heart failure in Atherosclerosis Risk in Communities Study European Americans (hazard ratio=1.16; P=0.004).
|
23247143 |
2013 |
|
rs12567209
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs12567209 in NOS1AP may serve as an independent predictor of all-cause death and SCD in patients with CHF, it is also associated with prolonged QTc interval in the Chinese Han population.
|
24418727 |
2014 |
|
rs1258130495
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This Arg16Gly genotype-dependent heterogeneity in clinical outcomes of HF was successfully validated in the second independent population.
|
30374408 |
2018 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The DD allele frequency is lower in Chinese, but the M235T variant of the angiotensinogen gene is more common in Chinese than whites; it is not known to what extent polymorphisms of the renin-angiotensin system affect clinical status or prognosis in Chinese patients with heart failure.
|
10097225 |
1999 |
|
rs13003941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-G-C-C-T haplotype of rs10932374-rs13003941-rs1595064-rs1595065-rs3748960 in the ErbB4 gene increased the risk of heart failure (odd ratio 1.35, 95% confidence interval [CI] 1.06-1.70; P = .014).
|
26844763 |
2016 |
|
rs1303946678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure.
|
15735607 |
2005 |
|
rs13058338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01).
|
23927520 |
2013 |
|
rs1320702652
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
|
24431031 |
2014 |