|
rs1076560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs1076560 nor rs2283265 significantly associated with heroin addiction.
|
31025317 |
2019 |
|
rs12364283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The enhancer rs12364283</span> occurs more frequently in heroin-dependent cases than controls (MAF 13% vs. 7%, respectively), revealing significant association with heroin addiction (p = 3.0E-06, OR 2.1).
|
31025317 |
2019 |
|
rs2283265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs1076560 nor rs2283265 significantly associated with heroin addiction.
|
31025317 |
2019 |
|
rs363332
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three <i>SLC18A2</i> SNPs (rs363332, rs363334 and rs363338) with heroin dependence (p<sub>final</sub> = 0.047).
|
30983500 |
2019 |
|
rs363334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three <i>SLC18A2</i> SNPs (rs363332, rs363334 and rs363338) with heroin dependence (p<sub>final</sub> = 0.047).
|
30983500 |
2019 |
|
rs363338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three <i>SLC18A2</i> SNPs (rs363332, rs363334 and rs363338) with heroin dependence (p<sub>final</sub> = 0.047).
|
30983500 |
2019 |
|
rs4648319
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup.
|
28854834 |
2019 |
|
rs255105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.
|
29953524 |
2018 |
|
rs279858
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of the reward network connections that mediates the effects of rs279858 on cognition would be disrupted by heroin addiction.
|
30061709 |
2018 |
|
rs1137070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heroin addiction and the rs1137070 variant interactively altered measures of GMV in the anterior cingulate cortex, orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function.
|
28345608 |
2017 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
|
27647760 |
2016 |
|
rs11030096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the chi-squared test, we found that rs7481311 (OR =1.275, 95% CI = 1.087-1.497, p = 0.009) and rs11030096 (OR =1.227, 95% CI = 1.049-1.436, p = 0.011) in the BNDFOS were associated with an increased risk of heroin addiction.
|
27647760 |
2016 |
|
rs11030104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
|
27647760 |
2016 |
|
rs17189632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that GRIN3A rs17189632 and GRIN3B rs2240158 may contribute to the susceptibility of heroin addiction.
|
27542340 |
2016 |
|
rs2240158
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that GRIN3A rs17189632 and GRIN3B rs2240158 may contribute to the susceptibility of heroin addiction.
|
27542340 |
2016 |
|
rs7481311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By contrast, the allele 'T' of rs7481311 in BDNFOS significantly elevated the risk of heroin addiction in the additive model, recessive model and dominant model (p < 0.05).
|
27647760 |
2016 |
|
rs988712
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By contrast, rs988712 located in BDNFOS showed a decreased risk of heroin addiction (OR =0.734, 95% CI = 0.582-0.925, p = 0.003).
|
27647760 |
2016 |
|
rs10078866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the potential association between heroin dependence and 8 single-nucleotide polymorphisms (rs686, rs4867798, rs1799914, rs4532, rs5326, rs265981, rs10078714, rs10078866) of DRD1, and the associations between single single-nucleotide polymorphism, haplotypes, and impulsive behavior.
|
25966176 |
2015 |
|
rs1122079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to identify the markers that contribute to the genetic susceptibility of heroin dependence, the potential association between heroin dependence and 10 single nucleotide polymorphisms (SNPs), including rs8077696, rs8070231, rs2292593, rs2292592, rs9916525, rs1122079, rs4790953, rs1530351, rs4791230 and rs2869577 of the RGS9 gene was evaluated using the MassARRAY system.
|
25591550 |
2015 |
|
rs11606194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p(corrected) = 0.04).
|
26227246 |
2015 |
|
rs1344706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We independently replicated both ZNF804A SNP associations in EAs: the rs7597593-T (P = 0.016) and rs1344706-A (P = 0.029) alleles both being associated with increased risk of heroin addiction, consistent with the prior report.
|
26382569 |
2015 |
|
rs1389752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively.
|
26384852 |
2015 |
|
rs1530351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results revealed that two SNPs (rs1530351 and rs4791230) located in the promoter region of the RGS9 gene, were significantly associated with heroin dependence (P<0.05).
|
25591550 |
2015 |
|
rs1816071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in GABRB2, namely rs6556547 (S1), rs1816071 (S3), rs18016072 (S5), and rs187269 (S29), previously associated with schizophrenia, were examined for their association with heroin dependence.
|
26561861 |
2015 |
|
rs187269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in GABRB2, namely rs6556547 (S1), rs1816071 (S3), rs18016072 (S5), and rs187269 (S29), previously associated with schizophrenia, were examined for their association with heroin dependence.
|
26561861 |
2015 |