|
rs10078866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the potential association between heroin dependence and 8 single-nucleotide polymorphisms (rs686, rs4867798, rs1799914, rs4532, rs5326, rs265981, rs10078714, rs10078866) of DRD1, and the associations between single single-nucleotide polymorphism, haplotypes, and impulsive behavior.
|
25966176 |
2015 |
|
rs10196867
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.
|
31462767 |
2019 |
|
rs1022563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found significant pointwise correlation of these three variants (rs1022563, rs2235749 and rs910080) with heroin dependence.
|
21382455 |
2011 |
|
rs1042114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previously, two single nucleotide polymorphisms (SNPs), OPRD1 921T > C and 80G > T, of the human delta opioid receptor gene were used in population-based studies of heroin dependence.
|
12116270 |
2002 |
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also in Caucasians, the genotype pattern, 1359G>A and -6274A>T, was significantly associated with heroin addiction experiment wise (P=0.0244).
|
20010914 |
2010 |
|
rs10494334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest association with vulnerability to develop heroin addiction, with experiment-wise significance (P=0.035), was found in Caucasians with the variant rs10494334, a variant in an unannotated region of the genome (1q23.3).
|
20520587 |
2010 |
|
rs1076560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs1076560 nor rs2283265 significantly associated with heroin addiction.
|
31025317 |
2019 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
|
27647760 |
2016 |
|
rs1079597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup.
|
28854834 |
2019 |
|
rs1079597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In single marker analysis the TaqIA (rs1800497) and TaqIB (rs1079597) variants were associated with heroin dependence.
|
23840506 |
2013 |
|
rs11030096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the chi-squared test, we found that rs7481311 (OR =1.275, 95% CI = 1.087-1.497, p = 0.009) and rs11030096 (OR =1.227, 95% CI = 1.049-1.436, p = 0.011) in the BNDFOS were associated with an increased risk of heroin addiction.
|
27647760 |
2016 |
|
rs11030104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
|
27647760 |
2016 |
|
rs1122079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to identify the markers that contribute to the genetic susceptibility of heroin dependence, the potential association between heroin dependence and 10 single nucleotide polymorphisms (SNPs), including rs8077696, rs8070231, rs2292593, rs2292592, rs9916525, rs1122079, rs4790953, rs1530351, rs4791230 and rs2869577 of the RGS9 gene was evaluated using the MassARRAY system.
|
25591550 |
2015 |
|
rs1137070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heroin addiction and the rs1137070 variant interactively altered measures of GMV in the anterior cingulate cortex, orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function.
|
28345608 |
2017 |
|
rs11503014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the intron 2 SNP rs11503014, not located in any haplotype block and potentially implicated in exon splicing, was independently associated with addiction, specifically heroin addiction (p < .005).
|
19833324 |
2010 |
|
rs11606194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p(corrected) = 0.04).
|
26227246 |
2015 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, 360 treatment-seeking African American male patients with single and comorbid DSM-IV lifetime diagnoses of alcohol, cocaine and heroin dependence and 187 African American male controls were genotyped for the triallelic 5-HTTLPR functional polymorphism in the 5-HT transporter gene (SLC6A4) and 16 haplotype-tagging single-nucleotide polymorphisms (SNPs) across HTR3B (including the functional rs1176744 Tyr129Ser) and HTR3A, genes encoding 5-HT3 receptors.
|
20838391 |
2011 |
|
rs12364283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The enhancer rs12364283</span> occurs more frequently in heroin-dependent cases than controls (MAF 13% vs. 7%, respectively), revealing significant association with heroin addiction (p = 3.0E-06, OR 2.1).
|
31025317 |
2019 |
|
rs130058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence of association was found between the functional SNP -161A>T (rs130058) and alcohol, cocaine, and heroin dependence (e.g., P = 0.03 and odds ratio (OR) = 1.2 (1.02, 1.42) in the combined European, Asian, African, and Hispanic populations).
|
23335468 |
2013 |
|
rs13306221
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings support a role of BDNF rs6265 and rs13306221 polymorphisms in heroin dependence and may guide future studies to identify other genetic risk factors for heroin dependence.
|
21458533 |
2011 |
|
rs1344706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We independently replicated both ZNF804A SNP associations in EAs: the rs7597593-T (P = 0.016) and rs1344706-A (P = 0.029) alleles both being associated with increased risk of heroin addiction, consistent with the prior report.
|
26382569 |
2015 |
|
rs135745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The result revealed a strong association between the rs135745 (3'-untranslated region) genotype distribution and heroin dependence (P = 0.0006).
|
24338102 |
2014 |
|
rs1360780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African-specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780.
|
24766650 |
2014 |
|
rs1389752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively.
|
26384852 |
2015 |
|
rs147247472
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.
|
31462767 |
2019 |