|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome.
|
23490278 |
2014 |
|
rs13266634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consistent with these findings, ZnT8KO mice and human individuals carrying rs13266634, a major risk allele of SLC30A8, exhibited increased insulin clearance, as assessed by c-peptide/insulin ratio.
|
24051378 |
2013 |
|
rs146695489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Octreotide-induced long QT syndrome in a child with congenital hyperinsulinemia and a novel missense mutation (p.Met115Val) in the ABCC8 gene.
|
24080777 |
2013 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of the functional promoter polymorphism rs266729 with lower serum adiponectin and increased insulin resistance in diverse ethnic groups may suggest a causal relationship between adiponectin level and insulin resistance.
|
23826141 |
2013 |
|
rs373115603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).
|
23488611 |
2013 |
|
rs776234219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).
|
23488611 |
2013 |
|
rs866477740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1).
|
23488611 |
2013 |
|
rs10423928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that schizophrenic patients with the A allele of GIPR rs10423928 are at risk of developing hyperinsulinemia when treated with antipsychotics.
|
21747410 |
2012 |
|
rs121913564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous MC4R mutations, M161T and I316S, identified separately in 2 subjects (3.2%), were associated with severe obesity, hyperphagia, hyperleptinemia and hyperinsulinemia.
|
22463805 |
2012 |
|
rs746906443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous MC4R mutations, M161T and I316S, identified separately in 2 subjects (3.2%), were associated with severe obesity, hyperphagia, hyperleptinemia and hyperinsulinemia.
|
22463805 |
2012 |
|
rs12970134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs17782313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs2014355
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (β) = -3.8% (-6.3%;-1.3%), P = 0.003), reduced incremental area under the insulin curve (β = -3.6% (-6.3%;-0.9%), P = 0.009), reduced acute insulin response (β = -2.2% (-4.2%;0.2%), P = 0.03), and with increased insulin sensitivity ISIMatsuda (β = 2.9% (0.5%;5.2%), P = 0.02).
|
21211036 |
2011 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Gln27Glu polymorphism in β2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis.
|
20738880 |
2010 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
rs225014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects.
|
20566590 |
2010 |
|
rs33997857
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype.
|
20356931 |
2010 |
|
rs4629571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with PCOS was observed.SNP rs4629571 was associated with increased insulin resistance.
|
19327767 |
2010 |
|
rs6708316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype.
|
20356931 |
2010 |
|
rs78311289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K650Q mutation was confirmed, but in contrast to the previous case, we additionally report findings of hyperinsulinemia.
|
20453470 |
2010 |
|
rs8192678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In overweight, nondiabetic Chinese adults, G482S polymorphism in the PPARGC1A gene is associated with hyperinsulinemia, HOMA-IR indices, and abdominal obesity.
|
19913841 |
2010 |
|
rs9997745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GG homozygotes for rs9997745 had increased MetS risk {odds ratio (OR) 1.90 [confidence interval (CI) 1.15, 3.13]; P = 0.01}, displayed elevated fasting glucose (P = 0.001) and insulin concentrations (P = 0.002) and increased insulin resistance (P = 0.03) relative to the A allele carriers.
|
20176858 |
2010 |
|
rs1016862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MC4R variants were detected in three patients: the known I169S variant was found in heterozygote state in two patients and a novel heterozygous Y302F mutation was detected in one 12-year-old girl (BMI = 34 kg/m(2), BMI z-score 2.7) who has been overweight since the second year of life and suffered from hyperinsulinemia (at the age of 12: fasting insulin 45 mU/ml, after oral glucose load max.300 mU/ml).
|
19214805 |
2009 |
|
rs1316381133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MC4R variants were detected in three patients: the known I169S variant was found in heterozygote state in two patients and a novel heterozygous Y302F mutation was detected in one 12-year-old girl (BMI = 34 kg/m(2), BMI z-score 2.7) who has been overweight since the second year of life and suffered from hyperinsulinemia (at the age of 12: fasting insulin 45 mU/ml, after oral glucose load max.300 mU/ml).
|
19214805 |
2009 |
|
rs2943641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies.
|
19734900 |
2009 |