|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension.
|
11128865 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs4305
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A polymorphism in ACE (rs4305) showed modest replication of association with increased hypertension (β: 0.06 mm Hg; SE: 0.01 mm Hg; meta-analysis: P=3.0×10(-5)).
|
21444836 |
2011 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms, located in the ACE (rs4291), angiotensinogen (rs5049) and (pro)renin receptor (rs2968915; rs5981008) genes were significantly associated with hypertension in two vascular disease populations of CAD (EUROPA) and cerebrovascular disease (PROGRESS; n = 3571).
|
21157371 |
2011 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
18413162 |
2008 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gene polymorphisms of adducin GLY460TRP, ACE I/D, AND AGT M235T in pediatric hypertension patients.
|
25262176 |
2014 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension.
|
10862638 |
2000 |
|
rs568401628
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the beta3-adrenergic receptor gene may favor the central adiposity gain.
|
14739355 |
2004 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension.
|
16981142 |
2006 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In studies conducted in several different populations, the M235T substitution in the angiotensinogen (AGT) locus has been associated with hypertension.
|
9034402 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One DNA polymorphism within exon 2- with threonine instead of methionine at position 235 (M235T) was found to be significantly associated with hypertension.
|
12169209 |
2003 |
|
rs568401628
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results are consistent with the thesis that the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated more often with the condition of high blood pressure than with normal blood pressure.
|
10100091 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension.
|
16685579 |
2006 |
|
rs1042309696
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.
|
18212314 |
2008 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Renin-angiotensin-aldosterone system (RAAS) polymorphisms such as the angiotensinogen-gene-M235T-, the angiotensin-conversion enzyme (ACE)-gene I/D- and the angiotensin-II-type 1-receptor-(AT1R)-A1166C-polymorphism have been implicated in renal insufficiency and hypertension.
|
19681973 |
2010 |
|
rs1415088003
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
|
26821322 |
2016 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T polymorphism of the angiotensinogen gene may be associated with a higher risk of hypertension.
|
11134677 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here.
|
15642127 |
2005 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |