|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.
|
21912683 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was an increased prevalence of hypertension and increased atria in Glu298Glu patients comparing with combined genotype Glu298Asp and Asp298Asp.
|
20079452 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant interaction between dietary fat intake and NOS3 Glu298Asp genotype with regards to hypertension status in either African Americans or whites (P for interaction=0.3 and 0.4, respectively).
|
19960019 |
2010 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
|
19169496 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension.
|
19132956 |
2009 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, meta-regression analysis indicated that the effect of the Glu298Asp genotype on the risk of hypertension might be dependent on total cholesterol status.
|
17762636 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT.
|
17306574 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Intron 4 B/B genotype was significantly associated with the hypertension group (P = 0.035), but disequilibrium of G894T and T-786C was absent between the two groups (P = 0.419 and P = 0.227), respectively.
|
17024134 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the E298D polymorphism contributes to the genetic susceptibility to hypertension.
|
15942458 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |