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rs10889677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.
|
31728561 |
2020 |
|
rs111033623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HSCT is the only curative therapy for XLP and this therapy should be urgently considered.What is Known:• SAP and XIAP deficiencies share common clinical feature, HLH, whereas they also have their own specific manifestations.• IBD affects 25-30% of XIAP-deficient patients, which has been reported in other countries especially in European country and Japan.What is New:• This is the largest patient cohort study of XLP in China.• We firstly summarized the clinical features and outcomes of Chinese XIAP-deficient patients and found only 1 in 22 patients developed IBD and diet background may contribute to it; Asian SAP-deficient patients carrying SH2D1A R55X mutation were more prone to HLH.
|
31754776 |
2020 |
|
rs2097432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the association between HLADQA1*05 and infliximab antibody formation, infliximab loss of response, treatment discontinuation and adverse drug events in patients with inflammatory bowel disease (IBD) METHODS: In a retrospective cohort study, infliximab-exposed patients with IBD (n = 262) were screened for the genetic variation, HLADQA1*05A>G (rs2097432).
|
31650614 |
2020 |
|
rs200550971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CB2-Q63R variant contributes to the risk for pediatric IBD, in particular CD.
|
27875353 |
2019 |
|
rs2413739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD).
|
31792371 |
2019 |
|
rs3129891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant genotypes at rs2066844, rs2066845, rs2066847 were not found, and only SNPs rs3129891 and rs77005575 were associated with enteric α-defensin expression in colonic IBD.
|
31403980 |
2019 |
|
rs34436714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between genotypes of rs34436714 of NLRP12 and serum tumor necrosis factor-alpha in inflammatory bowel disease: A case-control study.
|
31169706 |
2019 |
|
rs5743611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations with the risk of IBD were detected for the TLR1 rs5743611, TLR4 rs4986790, TLR4 rs4986791, and TLR6 rs5743810 polymorphisms in overall analyses.
|
30617966 |
2019 |
|
rs5743810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the TLR1 rs5743611, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810, and TLR9 rs352140 polymorphisms were significantly associated with the risk of IBD in Caucasians.
|
30617966 |
2019 |
|
rs6271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single non-synonymous SNP, rs6271 (Arg549Cys), had a significant association with IBD patients; the odds ratio was a 5.6 times higher SNP frequency in IBD patients compared to controls (p = 0.002).
|
30817802 |
2019 |
|
rs77005575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant genotypes at rs2066844, rs2066845, rs2066847 were not found, and only SNPs rs3129891 and rs77005575 were associated with enteric α-defensin expression in colonic IBD.
|
31403980 |
2019 |
|
rs77375493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, despite the absence of JAK2 V617F mutation in patients with IBD, the increased gene expression of JAK2 can be explained by another molecular mechanism such as regulation of gene expression at the transcriptional level which may play crucial roles in the pathogenesis of IBD.
|
31069840 |
2019 |
|
rs104895467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CTLA-4 (+49A/G) and NOD2/CARD15 (N852S) polymorphisms with inflammatory bowel disease in Turkish patients.
|
30213296 |
2018 |
|
rs10754558
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs12343867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CHRNA5 rs16969968 A variant interacts with smoking to influence IBD-related surgery.
|
29688464 |
2018 |
|
rs17250932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a genome-wide meta-analysis of 20,550 patients with CD, 17,647 patients with UC, and more than 40,000 individuals without IBD (controls), we found that rs2228145 (scaled to a 2-fold increase in s-IL6R) was associated with reduced risk of CD (odds ratio 0.876; 95% confidence interval 0.822-0.933; P = .00003) or UC (odds ratio 0.932; 95% confidence interval 0.875-0.996; P = .036).
|
29775600 |
2018 |
|
rs2234711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs2647087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We propose a simple and clinically implementable algorithm based on rs2647087 and TPMT genotypes for AZA selection and dosing for patients with IBD.
|
29270995 |
2018 |
|
rs3212217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
rs34688635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of 9,513 controls and 11,140 IBD patients of non-Jewish European ancestry did not reveal an association between p.D360N and IBD.
|
29091079 |
2018 |
|
rs36221701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed the existence of cis-regulated ASM around IBD susceptibility genes and the association between ASM SNP (rs36221701) genotype and SMAD3 expression, a susceptibility gene for IBD.
|
29547621 |
2018 |
|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
|
29706994 |
2018 |
|
rs3810936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD).
|
29873318 |
2018 |