|
rs2232365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, multifactor dimension reduction analysis suggested an increased risks of nearly 6-folds for ESRD and 23-folds for ARE cases under the six factors model which consists of tag-SNPs of FOXP3 (rs2232365, rs3761548, rs5902434 and rs2294021) and NF-kB1 (rs28362491 and rs696).
|
26794449 |
2016 |
|
rs2294021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, multifactor dimension reduction analysis suggested an increased risks of nearly 6-folds for ESRD and 23-folds for ARE cases under the six factors model which consists of tag-SNPs of FOXP3 (rs2232365, rs3761548, rs5902434 and rs2294021) and NF-kB1 (rs28362491 and rs696).
|
26794449 |
2016 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly higher occurrence of mutant genotypes of tag-SNPs of FOXP3 namely; rs2232365 and rs3761548 along with NF-kB1 namely; rs28362491 and rs696 in ESRD and ARE cases, suggested a risk association for ESRD and ARE.
|
26794449 |
2016 |
|
rs3448
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of rs3448 was associated with kidney complications (incidences of microalbuminuria, renal events and ESRD) in patients with type 1 diabetes.
|
26773925 |
2016 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly higher occurrence of mutant genotypes of tag-SNPs of FOXP3 namely; rs2232365 and rs3761548 along with NF-kB1 namely; rs28362491 and rs696 in ESRD and ARE cases, suggested a risk association for ESRD and ARE.
|
26794449 |
2016 |
|
rs4880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0.699; p = 0.018).GPX1 SNP alone did not alter the risk.
|
26881045 |
2016 |
|
rs6954996
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05).
|
26841219 |
2016 |
|
rs696
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, multifactor dimension reduction analysis suggested an increased risks of nearly 6-folds for ESRD and 23-folds for ARE cases under the six factors model which consists of tag-SNPs of FOXP3 (rs2232365, rs3761548, rs5902434 and rs2294021) and NF-kB1 (rs28362491 and rs696).
|
26794449 |
2016 |
|
rs702483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05).
|
26841219 |
2016 |
|
rs7652589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study shows that the A allele of rs7652589 is a risk allele for nephrolithiasis-related ESRD.
|
27739473 |
2016 |
|
rs7975232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, significant associations were seen between ApaI (rs7975232) polymorphism and ESRD risk in the heterozygote model (AC/ AA; P = 0.002; OR = 1.4, 95%CI = 1.14-1.83), homozygote model (CC/AA; P = 0.007; OR = 1.8, 95%CI = 1.17-2.85) genotypes for rs7975232, allelic model (P < 0.001; OR = 1.4, 95%CI = 1.15-1.64), dominant model (P = 0.001; OR = 1.5, 95%CI = 1.19-1.87), and recessive model (P = 0.046; OR = 0.6, 95%CI = 0.42-1.00) between cases and healthy controls Moreover, we found a significant correlation between the genotype and allele distribution of ApaI and intact parathyroid hormone (iPTH) levels, where allele C carriers have increased iPTH levels.
|
27323177 |
2016 |
|
rs836488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05).
|
26841219 |
2016 |
|
rs9374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05).
|
26841219 |
2016 |
|
rs995922697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped.
|
26881045 |
2016 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective of the present study is to evaluate the association, if any, of g.-2518A>G polymorphism (rs1024611) in MCP-1 gene in T2D cases with and without ESRD in the population of Punjab from North-West India.
|
25154422 |
2015 |
|
rs121917864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Toll-like receptors TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg677Trp and Arg753Gln) gene polymorphisms in end-stage renal disease patients on peritoneal dialysis.
|
26490558 |
2015 |
|
rs12431381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominal association extended to non-diabetic causes of ESKD in 1,459 additional AA cases (rs12431381 and rs12434215 p values 0.014-0.015; OR 0.77).
|
26496126 |
2015 |
|
rs12434215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs12434215 was weakly associated with T2D-ESKD in 557 EA T2D-ESKD cases contrasted with 753 EA non-nephropathy controls (p=0.019; OR 0.69, dominant model).
|
26496126 |
2015 |
|
rs1800469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir.
|
25871499 |
2015 |
|
rs1952034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three intronic RTN1 variants were nominally associated with T2D-ESKD in both discovery and replication analyses: rs1952034, rs12431381 and rs12434215 (additive models); combined T2D-ESKD (discovery+replication) p values were 0.015-3.0×10(-4) (ORs 0.67-0.77; minor alleles protective).
|
26496126 |
2015 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No such association of increased risk of ESRD was observed with TLR4 (Asp299Gly) Asp/Gly genotype and TLR2 polymorphisms.
|
26490558 |
2015 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR4 Thr399Ile genotype was associated with ESRD patients on PD; however, the genotype frequency was similar in PD patients with and without peritonitis.
|
26490558 |
2015 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Toll-like receptors TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg677Trp and Arg753Gln) gene polymorphisms in end-stage renal disease patients on peritoneal dialysis.
|
26490558 |
2015 |
|
rs743811
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HMOX1 rs743811 associated with chronic kidney disease stage (OR=3.0, P=0.0001) in the University of Illinois cohort and end-stage renal disease (OR=10.0, P=0.0003) in the Walk-Treatment of Pulmonary Hypertension and Sickle cell Disease with Sildenafil Therapy cohort.
|
26206798 |
2015 |
|
rs115489112
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two additional variants (H800R and Y1174H) were nominally associated with protection from end stage renal disease (P=0.036; odds ratio, 0.44; P=0.0084; odds ratio, 0.040, respectively) in the locus-wide single-variant association tests.
|
24948143 |
2014 |