|
rs10028805
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
|
26956414 |
2016 |
|
rs10069690
|
|
T |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
rs10069690
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
rs10165970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
rs1036935
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
|
28165464 |
2017 |
|
rs1036935
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL.
|
21554262 |
2011 |
|
rs1041569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results point to a possible association between the rs9514828 (CT vs. CC + TT; OR = 0.74; CI 95 % = 0.57; 0.97; p = 0.022) and rs1041569 (AT vs. AA + TT; OR = 0.72; CI 95 % = 0.54; 0.95; p = 0.021) of BAFF gene and rs61756766 (CC vs. CT; OR = 2.03; CI 95 % = 1.03; 3.99; p = 0.03) of BAFF-R gene and CLL risk.
|
27468724 |
2016 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population
|
31128065 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the BAX G125A SNPs was associated with a more advanced Binet stage at diagnosis, supporting a potential role for this variant in CLL disease progression.
|
17981213 |
2007 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the recessive model of inheritance, we found borderline associations between CLL risk and C/C genotype of rs1642785 (p=0.048); G/G genotype of rs2909430 (in men only; p=0.036) and Pro72Pro genotype of rs1042522 (in men only; p=0.045).
|
28364582 |
2017 |
|
rs10434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the A allele and the AA genotype of rs10434 were more frequent in B-CLL patients than in control subjects (0.54 vs 0.34; 27 vs 13%; respectively).
|
25966180 |
2015 |
|
rs1044873
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We provide evidence that rs1044873 in the IRF8 gene accounts for the initial GWAS signal for CLL risk.
|
23307532 |
2013 |
|
rs1044873
|
|
C |
0.810 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
rs1044873
|
|
C |
0.810 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Taken together, these data indicate that the MDR1 C3435T SNP may carry an increased risk of developing B-CLL, possibly by virtue of decreased protection against P-gp-substrate carcinogens.
|
17085864 |
2007 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity.
|
25586345 |
2015 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Here, we investigated whether common MDR1 single nucleotide polymorphisms (SNPs) (C1236T, C3435T, and G2677T/A) affect predisposition to chronic lymphocytic leukemia (CLL).
|
21463115 |
2011 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosis.
|
20496015 |
2011 |
|
rs104894226
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894226
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894228
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894228
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs1050976
|
|
T |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
rs10519097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
rs1057035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found nine statistically significant associations with CLL risk after FDR correction, seven in miRNA processing genes (rs3805500 and rs6877842 in DROSHA, rs1057035 in DICER1, rs17676986 in SND1, rs9611280 in TNRC6B, rs784567 in TRBP and rs11866002 in CNOT1) and two in pre-miRNAs (rs11614913 in miR196a2 and rs2114358 in miR1206).
|
25793711 |
2015 |