|
rs61754966
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A rare polymorphic variant of NBS1 that resulted in an isoleucine to valine substitution at amino acid position 171 (I171V) was first identified in childhood acute lymphoblastic leukemia.
|
24830725 |
2014 |
|
rs61754966
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In our previous study we showed that the germline p.I171V mutation in NBN may be considered as a risk factor in the development of childhood acute lymphoblastic leukemia (ALL) and some specific haplotypes of that gene may be associated with childhood leukemia.
|
24093751 |
2013 |
|
rs61754966
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs12721593
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs61753720
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the SNPs considered individually or within haplotypes (C1236T-G2677T/A-C3435T) were not significantly associated with childhood ALL.
|
17548681 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL.
|
15059065 |
2004 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the T/T genotype of the 3435C>T was also significantly higher in ALL (29/118 versus 10/96, p=0.006).
|
17568669 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T).
|
15717687 |
2005 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI = 0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62).
|
28845766 |
2017 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects.
|
19317599 |
2008 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 49 ARID5B SNPs interrogated, 10 were significantly associated with ALL susceptibility in both whites and Hispanics (P < .05), with risk alleles consistently more frequent in Hispanics than in whites. rs10821936 exhibited the most significant association in both races (P = 8.4 × 10(-20) in whites; P = 1 × 10(-6) in Hispanics), and genotype at this SNP was highly correlated with local Native American genetic ancestry (P = 1.8 × 10(-8)).
|
22291082 |
2012 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the studied Egyptian population, it can be concluded that the C allele, CC, and CT genotypes of <i>ARID5B</i> rs10821936 and the CA haplotype may be a susceptibility risk factor for pediatric and adult ALL.
|
31424309 |
2019 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17; rs10994982, P = 0.003, OR 1.72).
|
19684603 |
2009 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively).
|
28476190 |
2016 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7.
|
28817678 |
2017 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs10821936 polymorphism in ARID5B gene was associated with increased risk for ALL (P < 0.0001; OR = 1.27; 95%CI, 1.17-1.37).
|
23975371 |
2014 |
|
rs10821936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For ARID5B (rs10821936), homozygosity for the variant allele increased risk for the ALL/MLL- subgroup only (OR = 7.2, 95% CI = 2.5-20.6).
|
22422485 |
2013 |