|
rs61754966
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs12721593
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs61753720
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1799796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>XRCC3</i> rs1799794, rs45603942, rs1799796, and rs861530 were not significantly associated with the risk of childhood ALL in the Taiwanese population.
|
30532590 |
2018 |
|
rs861530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>XRCC3</i> rs1799794, rs45603942, rs1799796, and rs861530 were not significantly associated with the risk of childhood ALL in the Taiwanese population.
|
30532590 |
2018 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
|
25854371 |
2015 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
H63D mutation aggravates the iron overload status in pediatric ALL survivors.
|
28211293 |
2017 |
|
rs1695
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
rs569954362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs57725551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A meta-analysis was performed to examine the association between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and childhood ALL risk.
|
22529951 |
2012 |
|
rs138047632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense mutation affecting the 11th transmembrane domain of RFC (c.1250T>C; p.I417T) was found in one case of ALL at diagnosis.
|
18028428 |
2008 |
|
rs7088318
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A novel ALL susceptibility locus at 10p12.31-12.2 (BMI1-PIP4K2A, rs7088318, P = 1.1 × 10(-11)) was identified in the genome-wide association study, with independent replication in European Americans, African Americans, and Hispanic Americans (P = .001, .009, and .04, respectively).
|
23512250 |
2013 |
|
rs1800460
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A patient, exhibiting neutropenia on 6-MP was observed to be G460A-homozygote, while, two Acute Lymphoblastic Leukemia (ALL) patients with side-effects exhibited wild-type alleles.
|
20037211 |
2009 |
|
rs61754966
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A rare polymorphic variant of NBS1 that resulted in an isoleucine to valine substitution at amino acid position 171 (I171V) was first identified in childhood acute lymphoblastic leukemia.
|
24830725 |
2014 |
|
rs10417924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A signal of marginal significance for the rs10417924 polymorphism in the TGF-beta1 gene in B-cell lineage ALL showed up with both MDR and imputation techniques.
|
19229971 |
2009 |
|
rs2274407
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCC4 G912T SNP was genotyped in 145 Iranian Philadelphia-negative (Ph<sup>-</sup>) children with ALL using modified tetra-primer ARMS PCR and evaluated for possible association with 3-year disease-free survival (3DFS).
|
28550450 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accordingly, the co-presence of Tyr113His variant of EPHX1 and Arg399Gln variant of XRCC1 in the same individuals significantly increased the risk of childhood ALL up to 2.1-fold (OR = 2.1, P = 0.03).
|
21983886 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accumulated evidence has demonstrated that C677T and A1298C polymorphisms of the MTHFR gene are associated with acute lymphoblastic leukemia (ALL) risk, but the results have been inconclusive.
|
21702646 |
2011 |
|
rs35837782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After genotyping an additional 2525 cases and 3575 controls, we identify new susceptibility loci for BCP-ALL mapping to 10q26.13 (rs35837782, LHPP, P=1.38 × 10<sup>-11</sup>) and 12q23.1 (rs4762284, ELK3, P=8.41 × 10<sup>-9</sup>).
|
27694927 |
2017 |
|
rs11545078
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Allelic frequency of GGH 452C→T polymorphism was determined as 9.2% (CT, 11/71; TT, 1/71) in the ALL group, 8.0% (CT, 4/25; TT, 0/25) in the AML group, and 9.1% (TT, 4/132; T/C, 16/132) in the controls, respectively.
|
22568793 |
2012 |