|
rs1159838942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population.
|
21476145 |
2012 |
|
rs1494555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma.
|
20473910 |
2011 |
|
rs20541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
rs2855429
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, SNPs in RING1/RXRB (rs2855429), AIF1 (rs2857597), and BAT4 (rs3115667) were associated with NHL (P-trends ≤ 0.0002) and both diffuse large B-cell and follicular lymphomas (P-trends < 0.05).
|
21148756 |
2011 |
|
rs2857597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, SNPs in RING1/RXRB (rs2855429), AIF1 (rs2857597), and BAT4 (rs3115667) were associated with NHL (P-trends ≤ 0.0002) and both diffuse large B-cell and follicular lymphomas (P-trends < 0.05).
|
21148756 |
2011 |
|
rs3115667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, SNPs in RING1/RXRB (rs2855429), AIF1 (rs2857597), and BAT4 (rs3115667) were associated with NHL (P-trends ≤ 0.0002) and both diffuse large B-cell and follicular lymphomas (P-trends < 0.05).
|
21148756 |
2011 |
|
rs4760655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Most VDR variants (e.g., rs731236/TaqI, rs15444410/BsmI) were not associated with overall risk of NHL, but there was some evidence of a positive association between rs4760655 and follicular lymphoma risk (nominal P(trend) = 0.004, corrected P(trend) = 0.24).
|
21076051 |
2011 |
|
rs568408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Most VDR variants (e.g., rs731236/TaqI, rs15444410/BsmI) were not associated with overall risk of NHL, but there was some evidence of a positive association between rs4760655 and follicular lymphoma risk (nominal P(trend) = 0.004, corrected P(trend) = 0.24).
|
21076051 |
2011 |
|
rs9808753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
|
rs2228479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele at V92M was associated with FL (odds ratio (OR)=1.61, 95% confidence interval (CI) 1.08-2.39) and the r:wild type genotype with DLBCL (OR=0.58, 95% CI 0.38-0.89).
|
20129839 |
2010 |
|
rs7755224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility.
|
20639881 |
2010 |
|
rs10190751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A comparison of 183 patients with follicular lymphoma and 233 population controls revealed an increased lymphoma risk associated with the rs10190751 A genotype causing c-FLIP(R) expression.
|
19439735 |
2009 |
|
rs1308699981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we analyzed the FcgammaRIIIa 158 V/F, FcgammaRIIa 131 H/R, and FcgammaRIIb 232 I/T polymorphisms in a group of 188 patients with follicular lymphoma who were treated with chemotherapy without rituximab initially.
|
19672774 |
2009 |
|
rs3789068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in BCL2L11 were strongly related to follicular lymphoma only, particularly rs3789068 (OR(AG), 1.41; 95% CI, 1.10-1.81; OR(GG), 1.65; 95% CI, 1.25-2.19; P(trend) = 0.0004).
|
19336552 |
2009 |
|
rs172378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for C1qA([276A/G]) was done in 133 subjects with follicular lymphoma treated with single-agent rituximab, and correlation with clinical response was done using Cox regression analysis.
|
18927313 |
2008 |
|
rs3020314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four ESR1 SNPs were associated with follicular lymphoma (FL) in the U.S. study, with rs3020314 remaining associated with reduced risk of FL after multiple testing adjustments [odds ratio (OR) = 0.42, 95% confidence interval (CI) = 0.23-0.77) and replication in the German study (OR = 0.24, 95% CI = 0.06-0.94).
|
18636124 |
2008 |
|
rs372411058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping for C1qA([276A/G]) was done in 133 subjects with follicular lymphoma treated with single-agent rituximab, and correlation with clinical response was done using Cox regression analysis.
|
18927313 |
2008 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied deletions of GSTM1 and GSTT1, and the GSTP1 Ile(105)Val polymorphism in 89 patients with follicular lymphoma (FL).
|
17454600 |
2007 |
|
rs587781386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL).
|
17609875 |
2007 |
|
rs764562217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL).
|
17609875 |
2007 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The numbers of cases of particular subtypes were rather small for stable estimates, but we noted that the PON1 L55M AA allele, associated with slightly increased risk of non-Hodgkin's lymphoma (variant homozygotes OR, 1.36; 95% CI, 0.96-1.95), was most strongly associated with follicular non-Hodgkin's lymphoma and T-cell lymphoma, with ORs for variant homozygotes of 2.12 and 2.93, respectively.
|
16985026 |
2006 |
|
rs387907272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To the best of our knowledge, this is the first report of follicular lymphoma with monoclonal IgM and MYD88 L265P mutation.
|
31576141 |
2019 |
|
rs113488022
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL.
|
27121112 |
2016 |