Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416. 24304973

2014

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE We investigated the influence on gene expression of three established FL-associated loci-rs10484561, rs2647012, and rs6457327-by measuring their correlation with human-leukocyte-antigen (HLA) expression levels obtained from publicly available RNA-seq expression data sets from lymphoblastoid cell lines. 23246294

2013

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region. 22911334

2012

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions. 23025665

2012

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index. 21233317

2011

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined)  = 1.36, P(combined)  =  1.4 × 10(-7)). 21533074

2011

dbSNP: rs10484561
rs10484561
G 0.770 GeneticVariation GWASDB We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. 20639881

2010

dbSNP: rs10484561
rs10484561
0.770 GeneticVariation BEFREE We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. 20639881

2010

dbSNP: rs6457327
rs6457327
0.750 GeneticVariation BEFREE Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416. 24304973

2014

dbSNP: rs6457327
rs6457327
0.750 GeneticVariation BEFREE The analysis of NHL subtype-specific GWAS SNPs and overall NHL suggested a shared genetic susceptibility between FL and DLBCL, particularly involving variants in the major histocompatibility complex region (rs6457327 in 6p21.33: FL OR=1.29, p=0.013; DLBCL OR=1.23, p=0.013; NHL OR=1.22, p=5.9 × E-05). 24598796

2014

dbSNP: rs6457327
rs6457327
0.750 GeneticVariation BEFREE In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions. 23025665

2012

dbSNP: rs6457327
rs6457327
0.750 GeneticVariation BEFREE We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index. 21233317

2011

dbSNP: rs6457327
rs6457327
C 0.750 GeneticVariation GWASDB We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). 19620980

2009

dbSNP: rs6457327
rs6457327
0.750 GeneticVariation BEFREE We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). 19620980

2009

dbSNP: rs2647012
rs2647012
0.740 GeneticVariation BEFREE We confirmed that FL-protective rs2647012-linked variants, in high linkage disequilibrium with the extended haplotype DRB1*15:01-DQA1*01:02-DQB1*06:02, correlate with increased HLA-DQB1 expression. 24304973

2014

dbSNP: rs2647012
rs2647012
0.740 GeneticVariation BEFREE The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region. 22911334

2012

dbSNP: rs2647012
rs2647012
0.740 GeneticVariation BEFREE rs9275517 and rs3117222 in the HLA class II region were validated and inversely associated with FL risk (rs9275517: OR = 0.63, 95% CI = 0.55-0.73, p = 4.03 × 10(-11); rs3117222: OR = 0.66, 95% CI = 0.57-0.77, p = 1.45 × 10(-7)). rs9275517, which is in high linkage disequilibrium with rs2647012 (r2 = 0.9), was no longer associated with FL after conditioning on rs2647012. 23025665

2012

dbSNP: rs2647012
rs2647012
G 0.740 GeneticVariation GWASDB Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. 21533074

2011

dbSNP: rs2647012
rs2647012
0.740 GeneticVariation BEFREE Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. 21533074

2011

dbSNP: rs3117222
rs3117222
0.720 GeneticVariation BEFREE Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416. 24304973

2014

dbSNP: rs3117222
rs3117222
0.720 GeneticVariation GWASDB The rs3117222 association was independent of established FL SNPs, but not of the HLA-DPB1*0301 allele. 23025665

2012

dbSNP: rs3117222
rs3117222
0.720 GeneticVariation BEFREE The rs3117222 association was independent of established FL SNPs, but not of the HLA-DPB1*0301 allele. 23025665

2012

dbSNP: rs9275517
rs9275517
0.710 GeneticVariation GWASDB rs9275517 and rs3117222 in the HLA class II region were validated and inversely associated with FL risk (rs9275517: OR = 0.63, 95% CI = 0.55-0.73, p = 4.03 × 10(-11); rs3117222: OR = 0.66, 95% CI = 0.57-0.77, p = 1.45 × 10(-7)). rs9275517, which is in high linkage disequilibrium with rs2647012 (r2 = 0.9), was no longer associated with FL after conditioning on rs2647012. 23025665

2012

dbSNP: rs9275517
rs9275517
0.710 GeneticVariation BEFREE rs9275517 and rs3117222 in the HLA class II region were validated and inversely associated with FL risk (rs9275517: OR = 0.63, 95% CI = 0.55-0.73, p = 4.03 × 10(-11); rs3117222: OR = 0.66, 95% CI = 0.57-0.77, p = 1.45 × 10(-7)). rs9275517, which is in high linkage disequilibrium with rs2647012 (r2 = 0.9), was no longer associated with FL after conditioning on rs2647012. 23025665

2012

dbSNP: rs13198610
rs13198610
0.700 GeneticVariation GWASDB A meta-analysis of genome-wide association studies of follicular lymphoma. 23025665

2012