|
rs35998847
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A meta-analysis of genome-wide association studies of follicular lymphoma.
|
23025665 |
2012 |
|
rs6932542
|
|
|
0.700 |
GeneticVariation |
GWASDB |
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
|
21533074 |
2011 |
|
rs9275245
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A meta-analysis of genome-wide association studies of follicular lymphoma.
|
23025665 |
2012 |
|
rs9275572
|
|
|
0.700 |
GeneticVariation |
GWASDB |
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
|
21533074 |
2011 |
|
rs17749561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1.
|
25279986 |
2014 |
|
rs2621416
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416.
|
24304973 |
2014 |
|
rs3115667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, SNPs in RING1/RXRB (rs2855429), AIF1 (rs2857597), and BAT4 (rs3115667) were associated with NHL (P-trends ≤ 0.0002) and both diffuse large B-cell and follicular lymphomas (P-trends < 0.05).
|
21148756 |
2011 |
|
rs4938573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1.
|
25279986 |
2014 |
|
rs6054706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also observed an increased risk of FL for DEFB126 rs6054706 (allele risk OR = 1.39, P-trend = 0.033).
|
23055202 |
2013 |
|
rs7755224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility.
|
20639881 |
2010 |
|
rs2857597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, SNPs in RING1/RXRB (rs2855429), AIF1 (rs2857597), and BAT4 (rs3115667) were associated with NHL (P-trends ≤ 0.0002) and both diffuse large B-cell and follicular lymphomas (P-trends < 0.05).
|
21148756 |
2011 |
|
rs587776632
|
|
GAA |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776633
|
|
CT |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776634
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776635
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776636
|
|
GA |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776637
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs3789068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in BCL2L11 were strongly related to follicular lymphoma only, particularly rs3789068 (OR(AG), 1.41; 95% CI, 1.10-1.81; OR(GG), 1.65; 95% CI, 1.25-2.19; P(trend) = 0.0004).
|
19336552 |
2009 |
|
rs113488022
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL.
|
27121112 |
2016 |
|
rs113488022
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The performance of the BRAF V600E-specific VE1 antibody was compared with that of allele-specific polymerase chain reaction (PCR) in 22 formalin-fixed, paraffin-embedded (FFPE) specimens with HCL involvement, along with nine splenic marginal zone lymphomas (SMZLs), 10 follicular lymphomas (FLs), 10 mantle cell lymphomas (MCLs), and 10 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLLs).
|
25511147 |
2015 |
|
rs121913377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL.
|
27121112 |
2016 |
|
rs121913377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The performance of the BRAF V600E-specific VE1 antibody was compared with that of allele-specific polymerase chain reaction (PCR) in 22 formalin-fixed, paraffin-embedded (FFPE) specimens with HCL involvement, along with nine splenic marginal zone lymphomas (SMZLs), 10 follicular lymphomas (FLs), 10 mantle cell lymphomas (MCLs), and 10 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLLs).
|
25511147 |
2015 |
|
rs144848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The following genotypes in combination with hair dye use before 1980 were associated with FL risk: BRCA2 rs144848 AC+CC [odds ratio (OR) (95% confidence interval (CI)) 3.28(1.27-8.50)], WRN rs1346044 TT [OR(95% CI) 2.70(1.30-5.65)], XRCC3 rs861539 CT+TT [OR(95% CI) 2.76(1.32-5.77)], XRCC4 rs1805377 GG [OR(95% CI) 2.07(1.10-3.90)] and rs1056503 TT [OR(95% CI) 2.17(1.16-4.07)], ERCC1 rs3212961 CC [OR(95% CI) 1.93(1.00-3.72)], RAD23B rs1805329 CC [OR(95% CI) 2.28(1.12-4.64)], and MGMT rs12917 CC, rs2308321 AA, and rs2308327 AA genotypes [OR(95% CI) 1.96(1.06-3.63), 2.02(1.09-3.75), and 2.23(1.16-4.29), respectively].
|
25178586 |
2014 |
|
rs144848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population.
|
21476145 |
2012 |
|
rs3763313
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A meta-analysis of genome-wide association studies of follicular lymphoma.
|
23025665 |
2012 |