rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the meta-analysis, polymorphisms in HLA-DRB1*13 (odds ratio [OR], 2.96; confidence interval [CI], 1.93-4.56), HLA-DRB1*04 (OR, 1.40; CI, 1.02-1.93), HLA-DQB1*03 (OR, 2.86; CI, 1.57-5.21), HLA-A*33 (OR, 2.32; CI, 1.42-3.80), and HLA-B*44 (OR, 3.17; CI, 2.22-4.55) were associated with significantly increased risk of developing NP, whereas HLA-A*02 (OR, 0.64; CI, 0.47-0.87) conferred reduced risk and neither rs1799971 in OPRM1 (OR, 0.55; CI, 0.27-1.11) nor rs4680 in COMT (OR, 0.95; CI, 0.81-1.13) were significantly associated with NP.
|
29351172 |
2018 |
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy.
|
31021849 |
2019 |
rs4680
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study concludes that functional Val158Met polymorphism of COMT gene is not associated to increased susceptibility to neuropathic pain.
|
15862471 |
2005 |
rs1017715903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intermediate Charcot-Marie-Tooth disease due to a novel Trp101Stop myelin protein zero mutation associated with debilitating neuropathic pain.
|
22704856 |
2012 |
rs104894851
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype Y222X is associated with classic Fabry disease, with unexpectedly rapid deterioration of visual acuity, while T410A is associated with a milder Fabry disease, with ventricular hypertrophy and neuropathic pain.
|
12694230 |
2003 |
rs104894852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype Y222X is associated with classic Fabry disease, with unexpectedly rapid deterioration of visual acuity, while T410A is associated with a milder Fabry disease, with ventricular hypertrophy and neuropathic pain.
|
12694230 |
2003 |
rs10814130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Principal component analysis revealed that the SIGMAR1 variants -297G>T (rs10814130) and 5A>C (rs1800866) significantly lowered thermal detection and heat/pressure nociception in particular in neuropathic pain patients with mainly preserved somatosensory function.
|
30266269 |
2019 |
rs10950641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
rs121918457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a patient with Noonan syndrome with multiple lentigines (NSML) due to a PTPN11 (p.Thr468Met) mutation associated with hypertrophic neuropathy of lumbar plexus in an adult woman, initially referred for neuropathic pain.
|
26952712 |
2016 |
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the meta-analysis, polymorphisms in HLA-DRB1*13 (odds ratio [OR], 2.96; confidence interval [CI], 1.93-4.56), HLA-DRB1*04 (OR, 1.40; CI, 1.02-1.93), HLA-DQB1*03 (OR, 2.86; CI, 1.57-5.21), HLA-A*33 (OR, 2.32; CI, 1.42-3.80), and HLA-B*44 (OR, 3.17; CI, 2.22-4.55) were associated with significantly increased risk of developing NP, whereas HLA-A*02 (OR, 0.64; CI, 0.47-0.87) conferred reduced risk and neither rs1799971 in OPRM1 (OR, 0.55; CI, 0.27-1.11) nor rs4680 in COMT (OR, 0.95; CI, 0.81-1.13) were significantly associated with NP.
|
29351172 |
2018 |
rs1800866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicates lack of association of SIGMAR1 -297G>T and 5A>C genetic variants to susceptibility to develop chronic pain, but significant modulation of somatosensory function in neuropathic pain patients.
|
30266269 |
2019 |
rs28933979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy.
|
21504341 |
2011 |
rs4775319
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
rs4804217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
rs6277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic regulation of DRD2 function by 957C>T polymorphism thus seems to influence thermal and pain sensitivity, its modulation by rTMS, and susceptibility to neuropathic pain.
|
25180011 |
2014 |
rs6746030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neuropathic pain in two-generation twins carrying the sodium channel Nav1.7 functional variant R1150W.
|
25116815 |
2014 |
rs6796803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four common SNPs representing four genomic regions: 7q22.3 (rs10950641; SNX8; P = 3.39 × 10<sup>-14</sup>), 19p13.2 (rs4804217; PCP2; P = 2.95 × 10<sup>-9</sup>), 3q27.3 (rs6796803; KNG1; P = 6.42 × 10<sup>-9</sup>) and 15q22.2 (rs4775319; RORA; P = 1.02 × 10<sup>-8</sup>), suggesting SNX8, PCP2, KNG1 and RORA might be novel target genes for NP in patients with head and neck cancer.
|
29884837 |
2018 |
rs8065080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This demonstrates not only the functional influence of TRPV1 rs8065080 polymorphism itself; it further more underpins the relevance of genotyping-based approaches in both patients and surrogate models of neuropathic pain in healthy volunteers.
|
28817717 |
2017 |