|
rs1150757
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.
|
29769526 |
2018 |
|
rs28383224
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.
|
29769526 |
2018 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients.
|
30531019 |
2019 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed a significant genetic association between the variant rs117026326</span> and NMOSD (P = 1.09 × 10<sup>-11</sup>, OR = 2.535), however, the association with MS was not significant (P = .4289, OR = 1.129).
|
31520790 |
2019 |
|
rs2300747
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852).
|
28601281 |
2017 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 35 SNPs, only one, rs1800693 in the TNFRSF1A locus, was nominally associated with NMO (P = 0.045, OR = 1.550, 95% CI = 1.007-2.384).
|
24927785 |
2014 |
|
rs2300747
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk.
|
24655566 |
2014 |
|
rs1800693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the BDNF Val66Met polymorphism may be associated with optic nerve damage caused by acute ON attacks in NMOSD</span> patients.
|
31803011 |
2019 |
|
rs73366469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients.
|
30531019 |
2019 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the BDNF Val66Met polymorphism may be associated with optic nerve damage caused by acute ON attacks in NMOSD</span> patients.
|
31803011 |
2019 |
|
rs10168266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs10181656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs12044852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852).
|
28601281 |
2017 |
|
rs1234315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate whether TNFSF4 polymorphisms contribute to risk of NMOSD, four single-nucleotide polymorphisms (SNPs) (rs1234315, rs2205960, rs704840, and rs844648) were selected and genotyped in a cohort of 312 patients with NMOSD and 487 healthy controls.
|
29032462 |
2017 |
|
rs13426947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other three SNPs showed protections on NMOSD in dominant models (rs6074022, OR = 0.64, 95 % CI 0.42-0.95, P = 0.031; rs1883832, OR = 0.65, 95 % CI 0.43-0.97, P = 0.036; and rs4810485, OR = 0.63, 95 % CI 0.42-0.95, P = 0.029, respectively), but not significantly after Bonferroni corrections for multiple tests.
|
27578014 |
2017 |
|
rs3765459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicates that the rs3765459 variant in CD40 gene is associated with susceptibility to NMOSD.
|
27578014 |
2017 |
|
rs4810485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other three SNPs showed protections on NMOSD in dominant models (rs6074022, OR = 0.64, 95 % CI 0.42-0.95, P = 0.031; rs1883832, OR = 0.65, 95 % CI 0.43-0.97, P = 0.036; and rs4810485, OR = 0.63, 95 % CI 0.42-0.95, P = 0.029, respectively), but not significantly after Bonferroni corrections for multiple tests.
|
27578014 |
2017 |
|
rs56302466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this study identified a new NMOSD susceptibility variant, rs56302466, and suggested that CD58 polymorphisms are associated with the risk of NMOSD in Han Chinese.
|
28601281 |
2017 |
|
rs6074022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other three SNPs showed protections on NMOSD in dominant models (rs6074022, OR = 0.64, 95 % CI 0.42-0.95, P = 0.031; rs1883832, OR = 0.65, 95 % CI 0.43-0.97, P = 0.036; and rs4810485, OR = 0.63, 95 % CI 0.42-0.95, P = 0.029, respectively), but not significantly after Bonferroni corrections for multiple tests.
|
27578014 |
2017 |
|
rs704840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations of rs844648 (OR = 1.67, 95% CI 1.17-2.38, P = 0.005, Pcorr = 0.02) and rs704840 (OR = 1.75, 95% CI 1.17-2.63, P = 0.007, Pcorr = 0.027) with NMOSD occurrence were also observed under the recessive model.
|
29032462 |
2017 |
|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
|
28852993 |
2017 |
|
rs7601754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the G allele of rs7601754 displayed a protective effect against NMOSD (OR = 0.53, 95% CI 0.36-0.76, P <sub>corr</sub> = 0.006).
|
28852993 |
2017 |
|
rs844648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations of rs844648 (OR = 1.67, 95% CI 1.17-2.38, P = 0.005, Pcorr = 0.02) and rs704840 (OR = 1.75, 95% CI 1.17-2.63, P = 0.007, Pcorr = 0.027) with NMOSD occurrence were also observed under the recessive model.
|
29032462 |
2017 |