Gene: BDNF ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE We found no association between p.V66M or the additionally genotyped variant c.-46C > T and obesity, ADHD or eating disorders. 15457498

2005
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE We found no association between p.V66M or the additionally genotyped variant c.-46C > T and obesity, ADHD or eating disorders. 15457498

2005
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE No association was found between the BDNF G196A (Val66Met) polymorphism and diabetes or obesity. 17151862

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE No association was found between the BDNF G196A (Val66Met) polymorphism and diabetes or obesity. 17151862

2007
dbSNP: rs746682028
rs746682028
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE No association was found between the BDNF G196A (Val66Met) polymorphism and diabetes or obesity. 17151862

2007
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Association of the BDNF Val66Met variation with obesity in women. 18667348

2008
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Association of the BDNF Val66Met variation with obesity in women. 18667348

2008
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children. 20843981

2010
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried. 21527513

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. 21851847

2012
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE A common polymorphism of the BDNF genotype (Val66Met) has been associated with various forms of eating disorders, alterations in body mass index (BMI) values and obesity in adult populations. 21851847

2012
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our study replicates the statistically significant association of four SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265) with risk of central obesity in the Chinese children. 23424664

2013
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE In a partial replication of prior research, the obesity risk (G) allele at BDNF rs6265 was associated with greater weight regain across treatment arms (0.773 kg per risk allele), although results were of borderline statistical significance (P=0.051). 23628854

2013
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our aim is to elucidate whether the interaction between the Brain Derived Neurotrophic Factor val66met polymorphism and obesity status influences executive performance and frontal-subcortical brain structure. 24619555

2014
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Our aim is to elucidate whether the interaction between the Brain Derived Neurotrophic Factor val66met polymorphism and obesity status influences executive performance and frontal-subcortical brain structure. 24619555

2014
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity. 24708359

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity. 24708359

2015
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well. 25874530

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well. 25874530

2015
dbSNP: rs12291063
rs12291063
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE Binding and transactivation functions are both disrupted by substituting C for T. These findings provide a rationale for BDNF augmentation as a targeted treatment for obesity in individuals who have the rs12291063 CC genotype. 26526993

2015
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups. 27166632

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups. 27166632

2016
dbSNP: rs746682028
rs746682028
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups. 27166632

2016
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE BDNF rs6265 polymorphism is associated with BMI categories, and the BDNF Met/Met genotype has a protective role in obesity in healthy subjects, while this effect was not present in patients with CHD. 27608901

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.100 GeneticVariation BEFREE The functional BDNF Val66Met polymorphism (rs6265) has been associated with CHD, obesity and BMI. 27608901

2016