|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI.
|
21063808 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity.
|
21303735 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity.
|
21347432 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population.
|
21147891 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried.
|
21527513 |
2011 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both FTO rs8050136 (P(age, sex-adjusted)=0.019; odds ratio (OR) (95% confidence intervals (CI)): 1.35 (1.05, 1.73)) and GNPDA2 rs10938397 (P(age, sex-adjusted)=3 × 10(-3); OR (95% CI): 1.34 (1.11, 1.63)) were significantly associated with persistent central obesity.
|
21147891 |
2011 |
|
rs8050136
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
21706003 |
2011 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
|
21935397 |
2011 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
among South Indians, the rs9940128 A/G, rs11076023 A/T, and rs1588413 C/T variants of the FTO gene were associated with T2DM, whereas the rs8050136 C/A variant was associated with obesity.
|
21175269 |
2011 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In African-Americans, only the rs1421085 C allele was a determinant of obesity risk (OR = 1.17, p = 0.05), but was found to be protective against diabetes (OR = 0.79, p = 0.03).
|
20502638 |
2010 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children.
|
20843981 |
2010 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children.
|
20215774 |
2010 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |
|
rs8050136
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Variant rs8050136 lies within intron 1 of the FTO gene on chromosome 16 and marks a locus strongly associated with type 2 diabetes and obesity and widely replicated across many populations.
|
20009087 |
2010 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.).
|
19255736 |
2009 |
|
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
rs1421085
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively).
|
19073769 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations.
|
19265794 |
2009 |