|
rs28362491
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, our findings suggest that rs28362491 and rs5743708 polymorphisms were significantly associated with MO disease through acting by modulating serum CRP levels.
|
27507606 |
2016 |
|
rs28362491
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that ins/ins genotype of SNP rs28362491 is linked to MO with high-level ALT, AST, ALP, and GGT.
|
29664665 |
2018 |
|
rs324420
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings provide evidence for an endocannabinoid-related phenotype that may be identified by the combination of circulating anandamide levels with genotyping of the FAAH 385C>A; this phenotype is not exclusive to mono-ethnoracial populations nor to individuals with severe obesity.
|
26561012 |
2015 |
|
rs324420
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We were unable to find robust evidence of an association of the Pro129Thr</span> variant with severe obesity, and any related quantitative traits among the obese Greek subjects examined.
|
18819056 |
2008 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate the prevalence of beta(3)-adrenergic receptor (ADRB3) Trp64Arg polymorphism and its relationship with the metabolic syndrome in severe obesity.
|
17299491 |
2007 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity.
|
9416435 |
1997 |
|
rs587777230
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Interestingly, a morbid-obesity-associated R82* truncated mutant of CEP19 cannot ciliate nor interact with FOP and CEP350, indicative of a putative role for CEP19 in ciliopathies.
|
28659385 |
2017 |
|
rs587777230
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Another truncating mutation p.Arg82* has been reported as responsible for morbid obesity in a family; however, in the family we present, not all homozygotes are obese, although some are severely obese.
|
29127258 |
2018 |
|
rs738409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.
|
19844213 |
2010 |
|
rs738409
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin resistance and T2D susceptibility by testing a gene-environment interaction model with severe obesity.
|
22724004 |
2012 |
|
rs10487818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One rare SNP, rs10487818, located in intron 4 of NAMPT was associated with severe obesity, with a minor allele frequency of 1.6% in controls, 0.4% in the class III obese adults and, remarkably, 0% in the severely obese children.
|
19300429 |
2009 |
|
rs1064891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs1064891, located in the 3' UTR of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) gene, was nominally associated with obesity in combined analysis of cohorts 1 and 2 (P=0.007) and, in men that were lean or had severe obesity, with BMI (P=or<0.005).
|
18180783 |
2008 |
|
rs121913564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous MC4R mutations, M161T and I316S, identified separately in 2 subjects (3.2%), were associated with severe obesity, hyperphagia, hyperleptinemia and hyperinsulinemia.
|
22463805 |
2012 |
|
rs121913566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
N62S was found in homozygous form in five children with severe obesity from a consanguineous pedigree.
|
10903343 |
2000 |
|
rs12510549
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms within SLC2A9 (rs6855911, rs7442295, rs6449213, and rs12510549) were genotyped in the population-based prospective Bruneck Study (n = 800) and in a case-control study from Utah including 1,038 subjects recruited for severe obesity and 831 control subjects.
|
18487473 |
2008 |
|
rs1322837244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs13447331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, this study suggest that S127L may be the most frequent functional MC4R mutation leading to the severe obesity in general population and provides new insight into the functionality of population based variants of the MC4R.
|
24385306 |
2014 |
|
rs1799883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate whether the Ala54Thr polymorphism of the fatty acid binding protein 2 gene is associated with obesity and obesity with dyslipidemia in Japanese schoolchildren, we analyzed 370 children with morbid obesity and 463 control children of normal weight.
|
11866034 |
2001 |
|
rs1800949
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, a previously unexplored ENPP1 haplotype composed of SNPs rs1800949 and rs943003 showed suggestive evidence for association with adult-onset morbid obesity in Finns.
|
18551113 |
2008 |
|
rs1801282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
|
22410809 |
2012 |
|
rs1805096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors.
|
28096764 |
2016 |
|
rs1805097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data indicate that IRS2 is an influential gene in severe obesity and glucose intolerance in this population, whereas gene-based haplotypes of IRS2 have revealed heterogeneity in the behaviour of the Gly1057Asp mutation in relation to insulin resistance.
|
12687350 |
2003 |
|
rs1805134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors.
|
28096764 |
2016 |
|
rs1805192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
|
22410809 |
2012 |
|
rs199951903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate whether the 15497 G/A mtDNA polymorphism (G251S) in the cytochrome b subunit of respiratory complex III, which has been associated with obesity-related variables and lipid metabolism in a Japanese population, is associated with severe obesity also in adult Caucasians from southern Italy.
|
17015183 |
2006 |