|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study.
|
31004714 |
2019 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study.
|
31004714 |
2019 |
|
rs564343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed for the first time that the rs564343 in PACS1 was associated with risk of severe obesity in a non-European population.
|
28564656 |
2017 |
|
rs1805096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors.
|
28096764 |
2016 |
|
rs1805134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors.
|
28096764 |
2016 |
|
rs2076349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using whole-exome sequencing followed by genotyping, we have identified a low-frequency coding variant rs2076349 (V527M) in the laminin subunit β3 (LAMB3) gene showing strong association with morbid obesity and thereby risk of type 2 diabetes.
|
27431458 |
2016 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, our findings suggest that rs28362491 and rs5743708 polymorphisms were significantly associated with MO disease through acting by modulating serum CRP levels.
|
27507606 |
2016 |
|
rs9930506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the effect of sleeve gastrectomy and the influence of FTO rs9930506 polymorphism on Tie-2, angiopoietin-1 and angiopoietin-2 expression in morbid obesity.
|
27581034 |
2016 |
|
rs1322837244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs201408477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs4148325
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed total bilirubin levels, which are linked to fatty liver in severe obesity, and observed the strongest evidence for association with rs4148325 in UGT1A (P < 5.0 × 10(-93)), replicating previous findings.
|
25246029 |
2015 |
|
rs540467809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs750845408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs917346005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs13447331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, this study suggest that S127L may be the most frequent functional MC4R mutation leading to the severe obesity in general population and provides new insight into the functionality of population based variants of the MC4R.
|
24385306 |
2014 |
|
rs757139012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified 4 rare variants (p.I128T, p.Q152E, p.R581G, and p.T714A) in 4 children with Prader-Willi-like syndrome features (including severe obesity) and 4 other rare variants (p.T46R, p.E62K, p.H323Y, and p.D740H) in 7 morbidly obese adults.
|
23778136 |
2013 |
|
rs9932411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A ∼680 kb duplication, confirmed by real-time PCR and G-to-FISH analyses, was observed between ∼rs11859825 and rs9932411 in a 68-year-old male with severe obesity.
|
23591406 |
2013 |
|
rs121913564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous MC4R mutations, M161T and I316S, identified separately in 2 subjects (3.2%), were associated with severe obesity, hyperphagia, hyperleptinemia and hyperinsulinemia.
|
22463805 |
2012 |
|
rs1801282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
|
22410809 |
2012 |
|
rs1805192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
|
22410809 |
2012 |
|
rs3856806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
|
22410809 |
2012 |
|
rs746906443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous MC4R mutations, M161T and I316S, identified separately in 2 subjects (3.2%), were associated with severe obesity, hyperphagia, hyperleptinemia and hyperinsulinemia.
|
22463805 |
2012 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the linkage disequilibrium (LD) block structure of a region surrounding the candidate rs9939609 SNP and determine the best single nucleotide polymorphism (SNP) combination that explains the higher proportion of variability observed in children with severe obesity, including obese subjects from families with a very high occurrence of obesity.
|
22030988 |
2012 |
|
rs2239607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2268388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T alleles at the rs2268388 locus were overrepresented in women with severe obesity (18% vs. 10% in controls; OR 1.74 [95% confidence interval 1.30-2.47]), which was statistically significant after multiple-test adjustment (p=0.0004).
|
21908218 |
2011 |