Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800571
rs1800571
PPARG
A 0.700 CausalMutation CLINVAR

dbSNP: rs28362491
rs28362491
NFKB1 ; LOC105377621
0.020 GeneticVariation BEFREE Our results suggest that ins/ins genotype of SNP rs28362491 is linked to MO with high-level ALT, AST, ALP, and GGT. 29664665

2018
dbSNP: rs587777230
rs587777230
PIGX ; CEP19
0.020 GeneticVariation BEFREE Another truncating mutation p.Arg82* has been reported as responsible for morbid obesity in a family; however, in the family we present, not all homozygotes are obese, although some are severely obese. 29127258

2018
dbSNP: rs587777230
rs587777230
PIGX ; CEP19
0.020 GeneticVariation BEFREE Interestingly, a morbid-obesity-associated R82* truncated mutant of CEP19 cannot ciliate nor interact with FOP and CEP350, indicative of a putative role for CEP19 in ciliopathies. 28659385

2017
dbSNP: rs28362491
rs28362491
NFKB1 ; LOC105377621
0.020 GeneticVariation BEFREE Therefore, our findings suggest that rs28362491 and rs5743708 polymorphisms were significantly associated with MO disease through acting by modulating serum CRP levels. 27507606

2016
dbSNP: rs324420
rs324420
FAAH
0.020 GeneticVariation BEFREE Our findings provide evidence for an endocannabinoid-related phenotype that may be identified by the combination of circulating anandamide levels with genotyping of the FAAH 385C>A; this phenotype is not exclusive to mono-ethnoracial populations nor to individuals with severe obesity. 26561012

2015
dbSNP: rs738409
rs738409
PNPLA3
0.020 GeneticVariation BEFREE Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin resistance and T2D susceptibility by testing a gene-environment interaction model with severe obesity. 22724004

2012
dbSNP: rs738409
rs738409
PNPLA3
0.020 GeneticVariation BEFREE Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. 19844213

2010
dbSNP: rs324420
rs324420
FAAH
0.020 GeneticVariation BEFREE We were unable to find robust evidence of an association of the Pro129Thr</span> variant with severe obesity, and any related quantitative traits among the obese Greek subjects examined. 18819056

2008
dbSNP: rs4994
rs4994
ADRB3
0.020 GeneticVariation BEFREE To evaluate the prevalence of beta(3)-adrenergic receptor (ADRB3) Trp64Arg polymorphism and its relationship with the metabolic syndrome in severe obesity. 17299491

2007
dbSNP: rs4994
rs4994
ADRB3
0.020 GeneticVariation BEFREE Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity. 9416435

1997
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study. 31004714

2019
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study. 31004714

2019
dbSNP: rs564343
rs564343
PACS1
0.010 GeneticVariation BEFREE We showed for the first time that the rs564343 in PACS1 was associated with risk of severe obesity in a non-European population. 28564656

2017
dbSNP: rs1805096
rs1805096
LEPR
0.010 GeneticVariation BEFREE Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors. 28096764

2016
dbSNP: rs1805134
rs1805134
LEPR
0.010 GeneticVariation BEFREE Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of the <i>LEPR</i> gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors. 28096764

2016
dbSNP: rs2076349
rs2076349
LAMB3
0.010 GeneticVariation BEFREE Using whole-exome sequencing followed by genotyping, we have identified a low-frequency coding variant rs2076349 (V527M) in the laminin subunit β3 (LAMB3) gene showing strong association with morbid obesity and thereby risk of type 2 diabetes. 27431458

2016
dbSNP: rs5743708
rs5743708
TLR2
0.010 GeneticVariation BEFREE Therefore, our findings suggest that rs28362491 and rs5743708 polymorphisms were significantly associated with MO disease through acting by modulating serum CRP levels. 27507606

2016
dbSNP: rs9930506
rs9930506
FTO
0.010 GeneticVariation BEFREE We studied the effect of sleeve gastrectomy and the influence of FTO rs9930506 polymorphism on Tie-2, angiopoietin-1 and angiopoietin-2 expression in morbid obesity. 27581034

2016
dbSNP: rs1322837244
rs1322837244
QPCTL
0.010 GeneticVariation BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885

2015
dbSNP: rs201408477
rs201408477
POMC
0.010 GeneticVariation BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885

2015
dbSNP: rs4148325
rs4148325
UGT1A10 ; UGT1A8 ; UGT1A7 ; UGT1A6 ; UGT1A5 ; UGT1A9 ; UGT1A4 ; UGT1A1 ; UGT1A3
0.010 GeneticVariation BEFREE We analyzed total bilirubin levels, which are linked to fatty liver in severe obesity, and observed the strongest evidence for association with rs4148325 in UGT1A (P < 5.0 × 10(-93)), replicating previous findings. 25246029

2015
dbSNP: rs540467809
rs540467809
QPCTL
0.010 GeneticVariation BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885

2015
dbSNP: rs750845408
rs750845408
PCSK1 ; LOC101929710
0.010 GeneticVariation BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885

2015
dbSNP: rs917346005
rs917346005
CADM2
0.010 GeneticVariation BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885

2015