|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively.
|
23264405 |
2012 |
|
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis.
|
21364948 |
2011 |
|
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans.
|
21877190 |
2011 |
|
rs30187
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
rs30187
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
|
21743469 |
2011 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |
|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs27044 (p=9.37 x 10(-7)) and rs30187 (p=7.16 x 10(-6)) of ARTS1 were significantly associated with AS in Koreans.
|
19414429 |
2010 |
|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
199 multiplex families with AS with four non-synonymous single nucleotide polymorphisms (SNPs), three in the endoplasmic reticulum aminopeptidase 1 (ERAP1) gene (rs27044, rs10050860 and rs30187) and one in the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene (rs2549782), were genotyped and family-based association analyses were performed.
|
19433412 |
2010 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
By contrast, the GA heterozygous genotype of rs11209026 variant showed a significant decrease in AS patients compared with controls.
|
19522770 |
2009 |
|
rs30187
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A specific ERAP1 haplotype, rs27044/10050860/30187-CCT, was strongly associated with increased risk of AS in all 3 case-control cohorts (pooled odds ratio [OR] 1.81, 95% confidence interval [95% CI] 1.46-2.24; P=7x10(-8)), while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduced the disease risk (pooled OR 0.77, 95% CI 0.67-0.88; P=9x10(-5)).
|
19404951 |
2009 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis.
|
18199597 |
2008 |
|
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The primary SNP of interest in a previous study of inflammatory bowel disease (IBD) (Arg381Gln; rs11209026) was found to be protective against AS in the Newfoundland population (P=0.04) and in the Toronto population (P=0.04) in single-marker univariate analysis.
|
18383363 |
2008 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
No significant difference was found between the AS susceptibility and polymorphisms of rs27044 and rs27434.
|
30461632 |
2018 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our results indicated a difference in the mechanism of susceptibility loci in subsets of Zhejiang Han Chinese population and provided further evidence that rs27434 is the key polymorphism associated with AS in ERAP1 gene.
|
26350268 |
2016 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
ERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of AS.
|
26617903 |
2015 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our study also confirmed a weak association between ERAP1 (rs27434) and AS.
|
24666027 |
2014 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Except in rs27434 (P = 0.23), the significant correlation between ERAP1 polymorphisms and AS susceptibility has been detected in rs27044 (OR 1.57, P < 0.001), rs17482078 (OR 1.271, P < 0.001), rs10050860 (OR 0.772, P = 0.006), rs30187 (OR 1.348, P < 0.001), rs2287987 (OR 0.746, P < 0.001) and rs27037 (OR 1.257, P = 0.001).
|
21229357 |
2012 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively.
|
23264405 |
2012 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS.
|
21041274 |
2011 |
|
rs27434
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Two SNP (rs27434, p = 0.00039, and rs27529, p = 0.0083) in ERAP1 other than that reported previously were found to be significantly associated with AS.
|
21078719 |
2011 |
|
rs27434
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |
|
rs27434
|
|
A |
0.890 |
GeneticVariation |
GWASDB |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
|
20062062 |
2010 |