|
rs1922786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10<sup>-7</sup>) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively.
|
30902966 |
2019 |
|
rs315952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that IL-1α rs17561 and IL-1RN rs315952 polymorphisms may not be associated with susceptibility to TS in Chinese Han population.
|
26097611 |
2015 |
|
rs17561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that IL-1α rs17561 and IL-1RN rs315952 polymorphisms may not be associated with susceptibility to TS in Chinese Han population.
|
26097611 |
2015 |
|
rs3813929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no statistically significant associations were found between the other four variants (rs4714156, rs9357271, rs518147, and rs3813929) and the TS phenotype (P>0.05).
|
22914617 |
2012 |
|
rs518147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no statistically significant associations were found between the other four variants (rs4714156, rs9357271, rs518147, and rs3813929) and the TS phenotype (P>0.05).
|
22914617 |
2012 |
|
rs6313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
As neuroimaging studies allude to dopaminergic and serotonergic dysfunction in GTS and serotonin as an important factor for dopamine release, genotyping of common polymorphisms in the serotonergic receptor (HTR1A: C-1019G; HTR2A: T102C, His452Tyr, A-1438G; HTR2C: C-759T, G-697C) and transporter genes (SLC6A4) was carried out in 87 patients with GTS, compared with 311 matched controls.
|
20010450 |
2010 |
|
rs6313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study suggested that the HTR2A 102T/C and -1438A/G polymorphisms may not be associated with susceptibility to TS, and thus do not play a major role in the development of TS in the Chinese Han population.
|
25858583 |
2016 |
|
rs6311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD.
|
17241828 |
2007 |
|
rs6296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggested that the polymorphism of HTR1B C861G is not a risk factor for TS in Han Chinese population.
|
26123080 |
2017 |
|
rs1800044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We now report that a missense nucleotide change in the 5HT1A receptor gene produces a variant form of the 5HT1A receptor (Arg(219) to Leu) identified in DNA extracted from a TS patient.
|
8645269 |
1996 |
|
rs267606861
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Recently, a heterozygous W317X mutation in the histidine decarboxylase gene (HDC) was reported to be responsible for TS in a two-generation pedigree.
|
22095709 |
2012 |
|
rs267606861
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
|
rs6591256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphism at position rs6591256 in the GSTP1 gene revealed significant differences in the allele (p=0.0135) and genotype (p=0.0159) distributions between the TS patients and the control group.
|
24205873 |
2014 |
|
rs1805476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also strong evidence for a linkage between polymorphisms and TS using the TDT (rs1805476: TDT=5.447, df=1, P=0.024; rs1805502: TDT=5.233, df=1, P=0.027).
|
26321256 |
2015 |
|
rs1805502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also strong evidence for a linkage between polymorphisms and TS using the TDT (rs1805476: TDT=5.447, df=1, P=0.024; rs1805502: TDT=5.233, df=1, P=0.027).
|
26321256 |
2015 |
|
rs12459560
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs2504235
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.
|
25698199 |
2015 |
|
rs11264126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominally significant associations were identified between TS and rs11264126 and two haplotypes containing rs11264126 and rs12141243.
|
21184590 |
2011 |
|
rs12141243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominally significant associations were identified between TS and rs11264126 and two haplotypes containing rs11264126 and rs12141243.
|
21184590 |
2011 |
|
rs117648881
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated both the role of the insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and that of the Val-158-Met substitution in the catechol-O-methyl-transferase (COMT) gene in conferring susceptibility to TS.
|
11166081 |
2000 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs7868992
|
|
|
0.810 |
GeneticVariation |
BEFREE |
PCR-directed sequencing was used to evaluate the genetic contributions of three SNPs in COL27A1(rs4979356, rs4979357 and rs7868992) using haplotype relative risk (HRR) and transmission disequilibrium tests (TDT) with a total of 260 Tourette syndrome trios.
|
26235311 |
2015 |