|
rs313158
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed 16 TRPM7 tag-single-nucleotide polymorphisms (SNPs) (dbSNP: rs11854949, rs4775899, rs11635825, rs12905120, rs16973487, rs7173321, rs7163283, rs17520378, rs17520350, rs4775892, rs7174839, rs17645523, rs3109894, rs616256, rs11070795, and rs313158) from 245 white men who subsequently had an incident ischemic stroke and from 245 age- and smoking habit-matched white men who remained free of reported vascular disease during follow-up (controls).
|
19644062 |
2009 |
|
rs579459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms associated with plasma LDL-c and vascular risk in the general population (rs11206510 (PCSK9), rs1122608 (LDLR), rs579459 (ABO) and rs599839 (SORT1)) were genotyped in a prospective cohort study of 5482 patients with vascular disease.
|
24251769 |
2014 |
|
rs72653706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease.
|
21831958 |
2011 |
|
rs1967309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nested case-control study examining the rs1967309 SNP in 1427 cases and 1532 matched controls selected from the 12 092-patient Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients at a High Risk for Vascular Outcomes (ACCELERATE) trial, a randomized, double-blind, placebo-controlled phase 3 trial conducted in patients with high-risk vascular disease randomized from October 2012 through December 2013.
|
29525816 |
2018 |
|
rs34203073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It has been reported that the activating mutation, E133K, in the angiogenic factor VG5Q (formally named AGGF1) causes Klippel-Trenaunay Syndrome (KTS), a rare vascular disease associated with asymmetric overgrowth.
|
16443853 |
2006 |
|
rs2144151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multipoint linkage peak was located at marker rs2144151 in the ANGPT4 gene, which is a strong candidate gene for vascular disease because of its involvement in angiogenesis.
|
20596041 |
2010 |
|
rs749437638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
16564429 |
2006 |
|
rs759985000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of vascular diseases.
|
30150066 |
2018 |
|
rs1333049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, our data indicate for the first time that the C allele of rs1333049 in the vascular disease susceptibility locus is associated with VaD and LOAD, independent of traditional risk factors and the APOE ε4 genotype.
|
19664850 |
2011 |
|
rs4977574
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The lead SNP at the 9p21 locus (rs4977574) was associated with all four vascular diseases (P < 4 × 10(-3)), illustrating the functional pleiotropy of this locus.
|
23828831 |
2013 |
|
rs2303790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Similarly, rs2303790 was not associated with any vascular diseases or plaque.
|
29141072 |
2018 |
|
rs2303790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To detect cholesteryl ester transfer protein (CETP) levels, frequencies of CETP D442G and I 14A mutations and characteristics of abnormal lipids in patients with cardio-cerebro vascular diseases.
|
11940367 |
2002 |
|
rs2303790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We compared the genotype distribution of the D442G polymorphism and postprandial serum lipid levels between patients with and without VD in 414 hemodialysis patients.
|
10412772 |
1999 |
|
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We, therefore, evaluated the CFH genetic variant Y402H amongst 685 Caucasian individuals who subsequently developed arterial or venous thrombotic event (incident myocardial infarction (MI), ischaemic stroke, or venous thromboembolism) and amongst 685 age- and smoking-matched Caucasian individuals who remained free of reported vascular disease during follow-up (controls) within the Physicians' Health Study cohort.
|
16229850 |
2006 |
|
rs267606743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the COL4A1 p.Gly510Arg mutation has been previously identified in a family with HANAC (Hereditary Angiopathy with Nephropathy, Aneurysm and Cramps), a multisystemic disease featuring retinal arteriolar tortuosity.
|
25228067 |
2014 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate whether the FTO rs9939609 single nucleotide polymorphism (SNP), which is a risk factor for obesity and vascular diseases, is also associated with pregnancy complications including pre-eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB).
|
27768255 |
2016 |
|
rs755460305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Glu298Asp (G894T) polymorphic variant of eNOS has been associated with vascular disease, but functional data are lacking.
|
11298374 |
2001 |
|
rs80356814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LMNA 1908C/T polymorphism plays an important role in the development of cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes.
|
16117820 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution.
|
14698652 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to establish whether the C677T and the A1298C mutations have an impact on vascular disease in the Ashkenazi Jewish population.
|
10494095 |
1999 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalences of the C677T and A1298C genotypes did not differ significantly in 772 individuals with documented coronary artery disease (CAD), 137 individuals with deep-vein thrombosis (DVT), and 329 individuals without documented vascular disease.
|
11274015 |
2001 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, it is still controversial a direct association between C677T homozygosity and the occurrence of vascular disease is still controversial.
|
10477457 |
1999 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common mutation in methylenetetrahydrofolate reductase (MTHFR), 677C-->T, is associated with reduced enzyme activity, a thermolabile enzyme and mild hyperhomocysteinemia, a risk factor for vascular disease.
|
11395038 |
2001 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y).
|
22507617 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH).
|
26757363 |
2016 |