|
rs1042636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with VDD bearing the GG genotype of R990G SNPs are prone to have higher iPTH levels and lower calcium.
|
25695075 |
2015 |
|
rs10766197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.
|
26149120 |
2015 |
|
rs1459015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of results also indicated that the Sudanese carriers of the CC genotype of SNP rs1459015 had a higher risk of suffering from vitamin D deficiency (P=0.02).
|
26339419 |
2015 |
|
rs10741657
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.
|
27570856 |
2016 |
|
rs4588
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.
|
27570856 |
2016 |
|
rs2296651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with homozygous p.Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and blood lipids.
|
28835676 |
2017 |
|
rs4809959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, vitamin D deficiency significantly increased the risk of transitioning to SLE in those with two minor alleles at rs4809959 (adjusted OR: 4.90, CI 1.33 to 18.04).
|
27283331 |
2017 |
|
rs10741657
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Published articles provide evidence supporting a major role for the rs10741657 polymorphism of the CYP2R1 gene in determining 25(OH)D levels and the presence of vitamin D deficiency.
|
30120973 |
2018 |
|
rs4588
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS.
|
28008453 |
2018 |
|
rs4588
|
|
|
0.040 |
GeneticVariation |
BEFREE |
DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588).In conclusion, low frequency of vitamin D deficiency was found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus-host interaction.
|
29465575 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genotype risk score (GRS) calculated from rs7041, rs2242480 and rs2209314 shown a significantly negative association with 25(OH)D levels.
|
29153269 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS.
|
28008453 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588).In conclusion, low frequency of vitamin D deficiency was found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus-host interaction.
|
29465575 |
2018 |
|
rs1155563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants of GC rs16846876, rs17467825, rs2282679, rs3755967, rs2298850, rs4588, rs7041 and rs1155563, CYP3A4 rs2242480 and CYP24A1 rs2209314 were significantly associated with both 25(OH)D concentrations and vitamin D deficiency (25(OH)D < 15 ng/mL).
|
29153269 |
2018 |
|
rs2060793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS.
|
28008453 |
2018 |
|
rs2209314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype risk score (GRS) calculated from rs7041, rs2242480 and rs2209314 shown a significantly negative association with 25(OH)D levels.
|
29153269 |
2018 |
|
rs2242480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype risk score (GRS) calculated from rs7041, rs2242480 and rs2209314 shown a significantly negative association with 25(OH)D levels.
|
29153269 |
2018 |
|
rs2246709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interactions between seasons and CYP27A1 rs933994, CYP3A4 rs2246709 on plasma 25(OH)D concentrations were also observed.
|
29153269 |
2018 |
|
rs4809957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was transmission disequilibrium for allele G of rs4809957 in T2DM families, which was linked to vitamin D deficiency.
|
29428204 |
2018 |
|
rs10766196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes.
|
31206955 |
2019 |
|
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG+GA genotype of CYP2R1 rs12794714 and AA+AG genotype of CYP2R1 rs10766196 were associated with prevalent vitamin D deficiency in children with type 1 diabetes.
|
31206955 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G>A and rs7T41>G VDBP genes polymorphisms.
|
31359379 |
2019 |
|
rs1993116
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency.
|
30683615 |
2019 |
|
rs2239179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When comparing with wild-type homozygous and heterozygous genotype carriers with vitamin D sufficiency, hypovitaminosis D and insufficient participants carrying homozygous variant genotype of rs2239179 showed a higher risk of EH, increased by 113% (OR = 2.13, 95% CI: 1.20, 3.80); Notably, the detrimental effect of rs2239179 homozygous variant on EH became stronger in the case of serum 25(OH)D<sub>3</sub> <30 ng/ml.
|
31827258 |
2019 |
|
rs3918242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Vitamin D deficiency was also a predominant feature among all MS patients irrespective of their MMP9 genotypes of rs3918242, implying its association with MS activity in different courses of the disease.
|
31082619 |
2019 |