|
rs10741657
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Published articles provide evidence supporting a major role for the rs10741657 polymorphism of the CYP2R1 gene in determining 25(OH)D levels and the presence of vitamin D deficiency.
|
30120973 |
2018 |
|
rs10741657
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.
|
27570856 |
2016 |
|
rs10741657
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs10741657
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs12785878
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.
|
26149120 |
2015 |
|
rs2282679
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Using multiple logistic regression analysis, vitamin D deficiency was significantly associated with the GC rs2282679 genotype (odds ratio [OR] per C allele 1.80, 95% confidence interval CI 1.57-2.01), independent of established risk factors for vitamin D deficiency including age, sex, and BMI.
|
25370324 |
2015 |
|
rs12785878
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs12785878
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs2282679
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs2282679
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
20541252 |
2010 |
|
rs1428826948
|
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
|
20647424 |
2010 |
|
rs151344517
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias.
|
20725928 |
2010 |
|
rs1569534160
|
|
G |
0.700 |
SusceptibilityMutation |
CLINVAR |
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
|
20647424 |
2010 |
|
rs1163944538
|
|
GA |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1202430946
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1352010373
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1555939456
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1557781252
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1568523935
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs587778779
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs4588
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS.
|
28008453 |
2018 |
|
rs4588
|
|
|
0.040 |
GeneticVariation |
BEFREE |
DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588).In conclusion, low frequency of vitamin D deficiency was found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus-host interaction.
|
29465575 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genotype risk score (GRS) calculated from rs7041, rs2242480 and rs2209314 shown a significantly negative association with 25(OH)D levels.
|
29153269 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS.
|
28008453 |
2018 |
|
rs7041
|
|
|
0.040 |
GeneticVariation |
BEFREE |
DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588).In conclusion, low frequency of vitamin D deficiency was found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus-host interaction.
|
29465575 |
2018 |