|
rs12043259
|
|
|
0.700 |
GeneticVariation |
GWASDB |
NCK2 is significantly associated with opiates addiction in African-origin men.
|
23533358 |
2013 |
|
rs2377339
|
|
G |
0.700 |
GeneticVariation |
GWASDB |
NCK2 is significantly associated with opiates addiction in African-origin men.
|
23533358 |
2013 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study provides a better understanding on the neurobiological mechanisms that may underlie risk of addiction development in carriers of the A118G SNP in <i>OPRM1</i><b>SIGNIFICANCE STATEMENT</b> The pandemic of opioid drug abuse is associated with many socioeconomic burdens.
|
31109961 |
2019 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances.
|
26392368 |
2016 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The mu-opioid receptor (OPRM1) A118G polymorphism has been associated with decreased analgesic effects of opioids and predisposition to addiction.
|
23405975 |
2013 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The nonsynonymous OPRM1 rs1799971 might be a risk factor for addiction to opioids or heroin in an Asian population.
|
23651028 |
2013 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population.
|
22138325 |
2012 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent.
|
21912675 |
2011 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction.
|
19891732 |
2010 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction and analgesia phenotypes, we derived a mouse model possessing the equivalent nucleotide/amino acid substitution in the Oprm1 gene.
|
19528658 |
2009 |
|
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs324420
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
|
rs324420
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions.
|
26036940 |
2015 |
|
rs324420
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity.
|
19103437 |
2009 |
|
rs324420
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Moreover, this mutation appears to have arisen early in human evolution and this study validates the previous link between the FAAH P129T variant and vulnerability to addiction of multiple different drugs.
|
16972078 |
2006 |
|
rs324420
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This SNP, which converts a conserved proline residue in FAAH to threonine (P129T), suggests a potential role for the FAAH-endocannabinoid system in regulating addictive behavior.
|
15254019 |
2004 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior.
|
23288874 |
2013 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We have previously found an association with rs4680 and MAMP addiction.
|
21934638 |
2011 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women.
|
16499480 |
2006 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs1800497
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with chronic addiction exhibit reduced dopamine D2 receptor (DRD2) availability in the striatum, and the <i>DRD2</i> TaqIA (rs1800497) and C957T (rs6277) genetic polymorphisms have previously been linked to individual differences in striatal dopamine metabolism and clinical risk for alcohol and nicotine dependence.
|
28507526 |
2017 |
|
rs1800497
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction.
|
23683269 |
2013 |
|
rs1333045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses have shown that T A haplotype block (rs1333045 and rs1333048 respectively) significantly decreases risk of addiction, BP I, BP II, and MDD.
|
31773399 |
2020 |
|
rs1333048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses have shown that T A haplotype block (rs1333045 and rs1333048 respectively) significantly decreases risk of addiction, BP I, BP II, and MDD.
|
31773399 |
2020 |
|
rs4436578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariable analyses adjusting for indoor tanning frequency, appearance orientation, and depressive symptoms, variant genotypes (CC or CT) in two DRD2 dopamine receptor gene SNPs were associated with increased odds of indoor tanning addiction (rs4436578, odds ratio [OR]: 2.30, 95% confidence interval [CI]: 1.11-4.77; rs4648318, OR: 1.95, 95% CI: 1.02-3.72).
|
31185074 |
2020 |