|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy.
|
28859293 |
2017 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The common Ser96Ala human genetic variant of HRC strongly correlates with life-threatening ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy.
|
28784772 |
2017 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
|
18617481 |
2008 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings indicate that the HRC Ser96Ala variant increases the propensity of arrhythmogenic Ca(2+) waves in the stressed failing heart, suggesting a link between this genetic variant and life-threatening ventricular arrhythmias in human carriers.
|
21742996 |
2011 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy.
|
24125847 |
2013 |
|
rs3766871
|
|
|
0.020 |
GeneticVariation |
BEFREE |
RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure.
|
25773045 |
2015 |
|
rs3766871
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the A allele of rs3766871 in RYR2 not only associates with ventricular arrhythmias, but also serves as an independent predictor of sudden cardiac death, and the A allele of rs790896 in RYR2 is a protective factor against sudden cardiac death in patients with CHF.
|
20408814 |
2010 |
|
rs7626962
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This is the first report that the S1103Y variant is associated with a higher incidence of ventricular arrhythmias in blacks with heart failure and reduced ejection fraction.
|
21498565 |
2011 |
|
rs7626962
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study shows that mutation S1103Y does exist in the white population, and it is associated with a considerable risk of syncope, ventricular arrhythmia, ventricular fibrillation, and sudden death in this population.
|
12471205 |
2002 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |
|
rs104894503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.
|
14734051 |
2004 |
|
rs104894580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of candidate loci culminated in the identification of a heterozygous missense mutation (R67W) in KCNJ2, the gene encoding the inward-rectifying potassium current, Kir2.1, in 41 members of a kindred in which ventricular arrhythmias (13 of 16 female members [81%]) and periodic paralysis (10 of 25 male members [40%]) segregated as autosomal dominant traits with sex-specific variable expressivity.
|
12148092 |
2002 |
|
rs104894584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias.
|
22308236 |
2012 |
|
rs1049194905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs120074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the KCNQ1 S140G mutation can induce ventricular arrhythmia and lessen ventricular contractility under re-entrant conditions.
|
30108508 |
2018 |
|
rs121918600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atrial overdrive pacing completely prevented VA in 16 of 19 (84%) Casq2(-/-) and in 7 of 8 (88%) RyR2(R4496C/+) mice and significantly reduced ventricular premature beats in both CPVT models (P<0.05).
|
23295832 |
2013 |
|
rs121918604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three RyR2 missense mutations, P2328S, Q4201R, and V4653F, which occur in Finnish families, result in similar mortality rates of approximately 33% by age 35 years and a threshold heart rate of 130 bpm, above which exercise induces ventricular arrhythmias.
|
15197150 |
2004 |
|
rs1237080661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs1266360671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first mechanistic evidence that increased PLN inhibition may impact both SR Ca(2+) uptake and Ca(2+) release activities and suggests that the human R25C-PLN may be a prognostic factor for increased ventricular arrhythmia risk in DCM carriers.
|
25852082 |
2015 |
|
rs1355262401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In heterozygous mice with S282 gene substituted with alanine (S282A), we found ventricular arrhythmias with inhibition of Cx43 phosphorylation at both S282 and S279 in the hearts.
|
30981509 |
2019 |
|
rs137854600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The surviving infant was found to have a heterozygous mutation in SCN5A (R1623Q), previously reported as a de novo mutation causing neonatal ventricular arrhythmia and LQTS.
|
15184283 |
2004 |
|
rs1801253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |
|
rs1805120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs1805127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS.
|
26520166 |
2016 |
|
rs184934308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 rare variants (KCNQ1: c.1944C>T and SCN5A: c.3621C>T) showed an elevated allelic frequency (more than 1.5-fold) in the AMI_VA group when compared to the AMI group.
|
31751991 |
2020 |