|
rs1801253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |
|
rs755373114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KI mice harboring the p.Q1283H variant exhibited an increased predisposition to ventricular arrhythmias after catecholaminergic stress in the absence of cardiac structural abnormalities.
|
30571258 |
2018 |
|
rs1860561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Prevalence of ATP2A2 rs1860561 variant was 17% in patients without VT/VF and 4% in those with ventricular arrhythmia (p = 0.009).
|
24048583 |
2013 |
|
rs192749597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a loss-of-function variant, Ca<sub>v</sub>α<sub>1c</sub>-T1787M, present in 0.8% of the African population, as a new risk factor for ventricular arrhythmia.
|
30279520 |
2018 |
|
rs1554108172
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1355262401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In heterozygous mice with S282 gene substituted with alanine (S282A), we found ventricular arrhythmias with inhibition of Cx43 phosphorylation at both S282 and S279 in the hearts.
|
30981509 |
2019 |
|
rs5443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that the C825T polymorphism (P = 0.004), left ventricular ejection fraction (P = 0.009), and QRS-duration (P = 0.039) were independent determinants of severe ventricular arrhythmias.
|
16783490 |
2006 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy.
|
28859293 |
2017 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The common Ser96Ala human genetic variant of HRC strongly correlates with life-threatening ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy.
|
28784772 |
2017 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
|
18617481 |
2008 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings indicate that the HRC Ser96Ala variant increases the propensity of arrhythmogenic Ca(2+) waves in the stressed failing heart, suggesting a link between this genetic variant and life-threatening ventricular arrhythmias in human carriers.
|
21742996 |
2011 |
|
rs3745297
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy.
|
24125847 |
2013 |
|
rs1805127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS.
|
26520166 |
2016 |
|
rs1805120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs740952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs104894580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluation of candidate loci culminated in the identification of a heterozygous missense mutation (R67W) in KCNJ2, the gene encoding the inward-rectifying potassium current, Kir2.1, in 41 members of a kindred in which ventricular arrhythmias (13 of 16 female members [81%]) and periodic paralysis (10 of 25 male members [40%]) segregated as autosomal dominant traits with sex-specific variable expressivity.
|
12148092 |
2002 |
|
rs104894584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias.
|
22308236 |
2012 |
|
rs120074187
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs120074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the KCNQ1 S140G mutation can induce ventricular arrhythmia and lessen ventricular contractility under re-entrant conditions.
|
30108508 |
2018 |
|
rs201698592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 rare variants (KCNQ1: c.1944C>T and SCN5A: c.3621C>T) showed an elevated allelic frequency (more than 1.5-fold) in the AMI_VA group when compared to the AMI group.
|
31751991 |
2020 |
|
rs56984562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the LMNA R541C mutation should be considered not only in patients with malignant ventricular arrhythmia and LV local wall motion abnormalities, but also in classic dilated cardiomyopathy with profound segmental LV contractility defects.
|
19167105 |
2010 |
|
rs59301204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LMNA p.(Arg331Gln) carriers had a significantly better outcome regarding the composite end point (malignant ventricular arrhythmias, end-stage heart failure, or death) compared with carriers of other pathogenic <i>LMNA</i> mutations.
|
28790152 |
2017 |
|
rs761056344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first mechanistic evidence that increased PLN inhibition may impact both SR Ca(2+) uptake and Ca(2+) release activities and suggests that the human R25C-PLN may be a prognostic factor for increased ventricular arrhythmia risk in DCM carriers.
|
25852082 |
2015 |
|
rs3766871
|
|
|
0.020 |
GeneticVariation |
BEFREE |
RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure.
|
25773045 |
2015 |