|
rs1049194905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs1237080661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs1805120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs184934308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 rare variants (KCNQ1: c.1944C>T and SCN5A: c.3621C>T) showed an elevated allelic frequency (more than 1.5-fold) in the AMI_VA group when compared to the AMI group.
|
31751991 |
2020 |
|
rs201698592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 rare variants (KCNQ1: c.1944C>T and SCN5A: c.3621C>T) showed an elevated allelic frequency (more than 1.5-fold) in the AMI_VA group when compared to the AMI group.
|
31751991 |
2020 |
|
rs740952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association study identified a statistically significant difference in genotype frequency of KCNH2: c.1539C>T and KCNH2: c.1467C>T between the AMI and AMI_VA groups.
|
31751991 |
2020 |
|
rs750678689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 rare variants (KCNQ1: c.1944C>T and SCN5A: c.3621C>T) showed an elevated allelic frequency (more than 1.5-fold) in the AMI_VA group when compared to the AMI group.
|
31751991 |
2020 |
|
rs1355262401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In heterozygous mice with S282 gene substituted with alanine (S282A), we found ventricular arrhythmias with inhibition of Cx43 phosphorylation at both S282 and S279 in the hearts.
|
30981509 |
2019 |
|
rs764772142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A pathogenic mutation in RYR2 (p.P164S) is the likely cause of USD in a Chinese family associated with malignant ventricular arrhythmias.
|
29132927 |
2019 |
|
rs120074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the KCNQ1 S140G mutation can induce ventricular arrhythmia and lessen ventricular contractility under re-entrant conditions.
|
30108508 |
2018 |
|
rs192749597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a loss-of-function variant, Ca<sub>v</sub>α<sub>1c</sub>-T1787M, present in 0.8% of the African population, as a new risk factor for ventricular arrhythmia.
|
30279520 |
2018 |
|
rs45546039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rapid and effective response of the R222Q SCN5A to quinidine treatment in a patient with Purkinje-related ventricular arrhythmia and familial dilated cardiomyopathy: a case report.
|
29871609 |
2018 |
|
rs755373114
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KI mice harboring the p.Q1283H variant exhibited an increased predisposition to ventricular arrhythmias after catecholaminergic stress in the absence of cardiac structural abnormalities.
|
30571258 |
2018 |
|
rs59301204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LMNA p.(Arg331Gln) carriers had a significantly better outcome regarding the composite end point (malignant ventricular arrhythmias, end-stage heart failure, or death) compared with carriers of other pathogenic <i>LMNA</i> mutations.
|
28790152 |
2017 |
|
rs1805127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS.
|
26520166 |
2016 |
|
rs1266360671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first mechanistic evidence that increased PLN inhibition may impact both SR Ca(2+) uptake and Ca(2+) release activities and suggests that the human R25C-PLN may be a prognostic factor for increased ventricular arrhythmia risk in DCM carriers.
|
25852082 |
2015 |
|
rs761056344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first mechanistic evidence that increased PLN inhibition may impact both SR Ca(2+) uptake and Ca(2+) release activities and suggests that the human R25C-PLN may be a prognostic factor for increased ventricular arrhythmia risk in DCM carriers.
|
25852082 |
2015 |
|
rs121918600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atrial overdrive pacing completely prevented VA in 16 of 19 (84%) Casq2(-/-) and in 7 of 8 (88%) RyR2(R4496C/+) mice and significantly reduced ventricular premature beats in both CPVT models (P<0.05).
|
23295832 |
2013 |
|
rs1860561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Prevalence of ATP2A2 rs1860561 variant was 17% in patients without VT/VF and 4% in those with ventricular arrhythmia (p = 0.009).
|
24048583 |
2013 |
|
rs104894584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias.
|
22308236 |
2012 |
|
rs765835441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The surviving carriers of these mutations exhibited only minor, if any structural abnormalities, and two carriers of R3570W showed ventricular arrhythmias predominantly at rest.
|
19781797 |
2011 |
|
rs56984562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the LMNA R541C mutation should be considered not only in patients with malignant ventricular arrhythmia and LV local wall motion abnormalities, but also in classic dilated cardiomyopathy with profound segmental LV contractility defects.
|
19167105 |
2010 |
|
rs199473605
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study supports the concept that febrile illness predisposes individuals who carry a loss of function SCN5A mutation, such as V1340I, to fever-induced ventricular arrhythmias in BrS by significantly reducing the sodium currents in the hyperthermic state.
|
19648062 |
2009 |
|
rs794728708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Surface ECGs in 3- to 10-day-old mice showed that R176Q/+ mice developed more ventricular arrhythmias after provocation with epinephrine and caffeine.
|
20009080 |
2009 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |