|
rs12675595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype rs10958350-rs7016778-rs12675595 was associated with gooseflesh skin (global P < 0.0001), yawning (global P = 0.0001), and restlessness (global P < 0.0001) withdrawal symptoms.
|
24525640 |
2014 |
|
rs4292394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008).
|
22676193 |
2012 |
|
rs6600893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008).
|
22676193 |
2012 |
|
rs7439366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008).
|
22676193 |
2012 |
|
rs2066702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively).
|
21635275 |
2011 |
|
rs2242480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele types associated with more severe withdrawal symptoms are also associated with more severe side effects and less betel nut (Areca catechu) use (p = 0.009 for rs4646440, p = 0.0063 for rs2242480).
|
21902501 |
2011 |
|
rs3762894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively).
|
21635275 |
2011 |
|
rs4646440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele types associated with more severe wit</span>hdrawal symptoms are also associated with more severe side effects and less betel nut (Areca catechu) use (p = 0.009 for rs4646440, p = 0.0063 for rs2242480).
|
21902501 |
2011 |
|
rs8192475
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pharmacogenetic analysis showed a significant association between rs8192475 (R37H) in CHRNA3 and both higher craving after quitting and increased withdrawal symptoms over time in MT2.
|
21268243 |
2011 |
|
rs752949
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele frequencies of the G603A polymorphism did not differ significantly between the control subjects and either the entire sample of alcoholics or the alcoholics with severe physiological withdrawal symptoms.
|
11204345 |
2000 |