|
rs6688832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs6688832 AG genotype was associated with lower level of FSH (P = 0.039) and higher risk of hyperandrogenism (P = 0.016) in patients with PCOS.
|
26452272 |
2015 |
|
rs6688832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, the R453Q and D151A variants of the H6PD gene are associated with PCOS and obesity, respectively, and may contribute to the PCOS phenotype by influencing obesity, insulin resistance and hyperandrogenism.
|
22306327 |
2012 |
|
rs1061622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The opposite behaviors in terms of clinical expressivity detected for CAPN-UCSNP44 and TNFR2-M196R rare variants suggest these variants to be sensitizing and protective factors respectively in adrenal hyperandrogenism.
|
19039234 |
2009 |
|
rs1061622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.
|
12161545 |
2002 |
|
rs17782313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that the other genotypes for non-obese PCOS group, AG/GG for rs12970134 and CT/TT for rs17782313, are associated with hirsutism, loss of hair, hyperandrogenism and anti-Müllerian hormone in PCOS.
|
31429705 |
2019 |
|
rs10818854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs12478601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs13405728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs13429458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs2059807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs4385527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for age and BMI, variants in luteinizing hormone/choriogonadotropin receptor (LHCGR) (rs13405728), C9orf3 (rs4385527) and insulin receptor gene (INSR) (rs2059807) were strongly associated with OA (Padjust < 0.01, <0.001 and <0.05, respectively); rs4385527 in C9orf3 was strongly associated with HA (Padjust< 0.001); variants in the thyroid adenoma associated gene (THADA) (rs13429458 and rs12478601), DENN/MADD domain containing 1A (DENND1A)(rs10818854), and C9orf3 (rs4385527) were significantly associated with PCOM (Padjust < 0.01, <0.001, <0.05 and <0.001, respectively).
|
25586784 |
2015 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs1799964 showed an association with dietary habit, clinical hyperandrogenism and AAO.
|
23975191 |
2013 |
|
rs2930961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the minor allele frequency of rs2930961 was significantly different in hyperandrogenism of PCOS.
|
23876972 |
2013 |
|
rs10986105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The same allele of rs10986105 that increased the risk of PCOS also increased the risk of hyperandrogenism in women without PCOS from Iceland and demonstrated a stronger risk for PCOS defined by the National Institutes of Health criteria than the Rotterdam criteria.
|
22547425 |
2012 |
|
rs34603401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the R453Q and D151A variants of the H6PD gene are associated with PCOS and obesity, respectively, and may contribute to the PCOS phenotype by influencing obesity, insulin resistance and hyperandrogenism.
|
22306327 |
2012 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
rs8111699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the effects of a single nucleotide polymorphism (SNP) (rs8111699) in STK11 on endocrine-metabolic and body composition indexes before and after 1 year of metformin in 85 hyperinsulinemic girls with androgen excess, representing a continuum from prepuberal girls with a combined history of low birth weight and precocious pubarche over to postmenarchial girls with hyperinsulinemic ovarian hyperandrogenism.
|
20357370 |
2010 |
|
rs140510483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While infrequent variations of T329I correlated with obesity, V208I was associated with endocrine parameters related to hyperandrogenism.
|
19820907 |
2009 |
|
rs2282440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While infrequent variations of T329I correlated with obesity, V208I was associated with endocrine parameters related to hyperandrogenism.
|
19820907 |
2009 |
|
rs2414096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several studies have reported the association of the SNP rs2414096 in the CYP19 gene with hyperandrogenism, which is one of the clinical manifestations of polycystic ovary syndrome (PCOS).
|
20015405 |
2009 |
|
rs2491132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While infrequent variations of T329I correlated with obesity, V208I was associated with endocrine parameters related to hyperandrogenism.
|
19820907 |
2009 |
|
rs1489441940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the paraoxonase -108 C-->T variant and the ApaI polymorphism in the IGF2 gene are associated with PCOS and might contribute to increased oxidative stress, insulin resistance, and hyperandrogenism in this prevalent disorder.
|
15181035 |
2004 |
|
rs2281939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism.
|
12849814 |
2003 |
|
rs1801278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To test the hypothesis that lower sex hormone-binding globulin (SHBG) concentrations are associated with heterozygosity for the G972R variant of the IRS-1 gene among adolescent girls with a history of precocious pubarche (PP) and hyperinsulinemic ovarian hyperandrogenism.Association study.Academic research environment.
|
12477526 |
2002 |
|
rs4994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although other studies suggest that the W64R variant is associated with the development of obesity and insulin resistance, we cannot demonstrate that it has a major effect on BMI in children with premature pubarche or in adolescent girls with hyperandrogenism.
|
10689004 |
2000 |