|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To date, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of XFG.
|
20431720 |
2010 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was no significant difference in the distributions of rs1048661, rs2165241, and rs3825942 between XFS and XFG.
|
20142848 |
2010 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In both case-control and family materials, significant association for allele G of rs1048661 (P=2.65 x 10(-5); P=0.0007), allele G of rs3825942 (P=2.24 x 10(-8); P=0.49) and allele T of rs2165241 (P=2.62 x 10(-13); P<0.0001) was found in XFS/XFG.
|
19343041 |
2009 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of rs3825942 has been shown to be associated with XFS/XFG in all populations studied to date.
|
19503743 |
2009 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After controlling for rs3825942 and rs2165241, the association between rs1048661 and XFS/XFG remained significant (p=3.6 x 10(-7)).
|
19936304 |
2009 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TT genotype in the single nucleotide polymorphism (SNP) rs1048661 and the GG genotype in the SNP rs3825942 in exon 1 of LOXL1 were significantly associated with an increased risk of XFG under recessive models (chi(2) test, p=5.34 x 10(-34) and p=2.1 x 10(-8), respectively).
|
18552979 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).
|
18421074 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the previously reported association of three SNPs (rs1048661, rs2165241, and rs3825942) in our independent XFG population (single SNP p-values were 0.001-0.02).
|
18334928 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Out of the two non-synonymous SNPs in exon 1 of the LOXL1 gene, rs3825942 has a significant association with XFS cases in the patients of the southern Indian population.
|
18334947 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Frequencies of the T allele of rs1048661 and the G allele of rs3825942 were significantly higher in XFS patients than in control subjects (rs1048661: 99.4% versus 55.0%; rs3825942: 99.4% versus 85.3%; p<0.0001).
|
18636115 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs of LOXL1 (rs1048661; Arg141Leu and rs3825942; Gly153Asp) are highly associated with XFS in the Japanese population.
|
18648524 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Strong association with the three LOXL1 common sequence variants was seen in both the PEX and PEXG patient groups independent of their geographic origin (rs2165241, combined OR = 3.42, P = 1.28 x 10(-40); rs1048661, OR = 2.43, P = 2.90 x 10(-19); and rs3825942, OR = 4.87, P = 8.22 x 10(-23)).
|
18385063 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We evaluated the association of three LOXL1 variants (rs1048661, rs3825942, and rs2165241) in 142 Japanese patients with exfoliation syndrome (EX; n=59) and exfoliation glaucoma (EG; n=83) as well as in 251 control patients aged 70 years or older with primary open-angle glaucoma (PG; n=40), normal tension glaucoma (NG; n=54), and cataract (CT; n=157).
|
18958304 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results indicate that the G153D LOXL1 variant is significantly associated with an increased risk of pseudoexfoliation and pseudoexfoliation glaucoma in an ethnically diverse patient population from the Northeastern United States.
|
18254956 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For the LOXL1 gene, individual alleles of rs1048661 (G), rs3825942 (G), and rs2165241 (T) are highly associated with XFS and XFG in American and European populations.
|
18385788 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After a standard eye examination protocol we genotyped SNPs rs2165241and rs3825942 in 62 XFG or exfoliation syndrome (XFS) patients and 170 normal controls.
|
18287813 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two non-synonymous polymorphisms (rs1048661 G>T and rs3825942 G>A) of lysyl oxidase-like protein 1 (LOXL1), a monoamine oxidase that catalyzes the polymerization of tropoelastin to elastin, were found to be associated with increased risk for XFS and exfoliation glaucoma (XFG).
|
18483563 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs1048661 and rs3825942 of the LOXL1 gene seem to be highly associated with XFS in the Japanese population, but a different polymorphism of LOXL1 may cause the development of XFS in the Japanese population.
|
18201684 |
2008 |
|
rs3825942
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Strong associations were observed for all three SNPs of LOXL1 for XFS (odds ratio [OR] = 13.56, P = 3.39 x 10(-28) for allele T of rs1048661; OR = 10.71, P = 1.49 x 10(-7) for allele G of rs3825942; and OR = 4.55, P = 5.33 x 10(-4) for allele C of rs2165241) and XFG (OR = 25.21, P = 1.44 x 10(-34) for allele T of rs1048661; OR = 11.02, P = 1.40 x 10(-7) for allele G of rs3825942; and OR = 11.89, P = 4.76 x 10(-6) for allele C of rs2165241).
|
18450598 |
2008 |
|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs3825942
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
|
17690259 |
2007 |
|
rs893818
|
|
|
0.810 |
GeneticVariation |
BEFREE |
With reference to <i>LOXL1</i>, the rs41435250 resulted as a risk factor and rs893818 as a protective factor for XFS/XFG in the Uygur populations.
|
31192002 |
2019 |
|
rs893818
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.
|
24938310 |
2014 |
|
rs893818
|
|
T |
0.810 |
GeneticVariation |
GWASCAT |
Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.
|
24938310 |
2014 |
|
rs2165241
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our previous data suggested that three single-nucleotide polymorphisms (SNPs), rs1048661, rs3825942, and rs2165241, of the lysyl oxidase-like 1 gene (<i>LOXL1</i>) are significantly associated with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG).
|
31192002 |
2019 |