|
rs121913675
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs121913676
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs121913677
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs4938723
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P(h)=0.187, OR=1.10, 95%CI=1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P(h)=0.113, OR=1.11, 95%CI=1.01-1.23 for C vs. T; P(h)=0.121, OR=1.19, 95%CI=1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P(h)=0.342, OR=0.66, 95%CI=0.47-0.92 for CC vs. TT; P(h)=0.519, OR=0.67, 95%CI=0.49-0.93 for CC vs. CT/TT; P(h)=0.443, OR=0.71, 95%CI=0.51-0.99 for CC/TT vs. CT).
|
25475831 |
2015 |
|
rs4938723
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks.
|
25201061 |
2014 |
|
rs145204276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer.
|
30013899 |
2018 |
|
rs1760893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG genotype at rs1760893 was also associated with enhanced hepatocellular cancer susceptibility (OR=1.46, 95% CI=1.05-2.03, P=0.02).
|
27305982 |
2016 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subgroup analyses by cancer types, we found that the hOGG1 Ser326Cys polymorphism may increase hepatocellular cancer and colorectal cancer risks, but decrease the risk of oral cancer.
|
25323581 |
2015 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
|
rs750521832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
|
rs1302103336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHK2 1100delC, IVS2+1G>A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population.
|
23107771 |
2013 |
|
rs17879961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHK2 1100delC, IVS2+1G>A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population.
|
23107771 |
2013 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C282Y homozygosity is associated with increased risk of colorectal cancer and hepatocellular cancer in men.
|
23281741 |
2013 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggests the participation of XRCC1 Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians.
|
24205095 |
2013 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
rs386656364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A7 polymorphisms were present in 93.2% of hepatocellular cancer patients, 74.5% carried the UGT1A7*3 allele (P < 0.001; OR, 10.76; 95% CI, 4.75-24.38), which combines the W208R, N129K, and R131K mutations and encodes a protein with low carcinogen detoxification activity.No UGT1A9 polymorphisms were detected.
|
11677206 |
2001 |
|
rs771314938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A7 polymorphisms were present in 93.2% of hepatocellular cancer patients, 74.5% carried the UGT1A7*3 allele (P < 0.001; OR, 10.76; 95% CI, 4.75-24.38), which combines the W208R, N129K, and R131K mutations and encodes a protein with low carcinogen detoxification activity.No UGT1A9 polymorphisms were detected.
|
11677206 |
2001 |
|
rs879625015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A7 polymorphisms were present in 93.2% of hepatocellular cancer patients, 74.5% carried the UGT1A7*3 allele (P < 0.001; OR, 10.76; 95% CI, 4.75-24.38), which combines the W208R, N129K, and R131K mutations and encodes a protein with low carcinogen detoxification activity.No UGT1A9 polymorphisms were detected.
|
11677206 |
2001 |