|
rs12051350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs1361241029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs138280963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs1383461329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A16V (C→T) mutation in PRSS1, which encodes a cationic trypsinogen and has a mutation associated with hereditary pancreatitis and pancreatic adenocarcinoma, was observed in 40% (8/20) (7/17 of ETV6 translocation-positive and 1/3 of ETV6 translocation-negative secretory carcinomas).
|
31822803 |
2019 |
|
rs1435047610
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs202003805
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A16V (C→T) mutation in PRSS1, which encodes a cationic trypsinogen and has a mutation associated with hereditary pancreatitis and pancreatic adenocarcinoma, was observed in 40% (8/20) (7/17 of ETV6 translocation-positive and 1/3 of ETV6 translocation-negative secretory carcinomas).
|
31822803 |
2019 |
|
rs764152905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs770380303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed segregation of the c.4249A>G SMG1 variant in 3 affected relatives in a FPC kindred, and we found c.103G>A to be a recurrent SMG1 variant associating with PC in both the discovery and validation series.
|
31469826 |
2019 |
|
rs876658923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A16V (C→T) mutation in PRSS1, which encodes a cationic trypsinogen and has a mutation associated with hereditary pancreatitis and pancreatic adenocarcinoma, was observed in 40% (8/20) (7/17 of ETV6 translocation-positive and 1/3 of ETV6 translocation-negative secretory carcinomas).
|
31822803 |
2019 |
|
rs121909235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pancreatic adenocarcinoma with a germline PTEN p.Arg234Gln mutation.
|
28755079 |
2018 |
|
rs121913529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mice harboring a G12D activating Kras mutation are among the most heavily studied models in the field of pancreatic adenocarcinoma (PDAC) research. miRNAs are differentially expressed in PDAC from patients and mouse models of PDAC.
|
27541609 |
2017 |
|
rs730881394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a woman with variant AT with two novel mutations in ATM (IVS14+2T>G and 5825C>T, p.A1942V) who died at age 48 with pancreatic adenocarcinoma.
|
24090759 |
2013 |
|
rs773379832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a woman with variant AT with two novel mutations in ATM (IVS14+2T>G and 5825C>T, p.A1942V) who died at age 48 with pancreatic adenocarcinoma.
|
24090759 |
2013 |
|
rs587778883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report that changes in miR expression patterns during progression of normal tissues to invasive pancreatic adenocarcinoma in the p48-Cre/LSL-Kras(G12D) mouse model mirrors the miR changes observed in human pancreatic cancer tissues. miR-148a/b and miR-375 expression were found decreased whereas miR-10, miR-21, miR-100 and miR-155 were increased when comparing normal tissues, premalignant lesions and invasive carcinoma in the mouse model.
|
21738581 |
2011 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although, no statistically significant differences were observed in the distribution of MTHFR genotype or allele frequencies between patients and control groups, the results showed an increased frequency of homozygotes for MTHFR C677T polymorphism in chronic pancreatitis patients (14%) and a decreased frequency in pancreatic adenocarcinoma patients (5%) in comparison to the control group (8%).
|
18636416 |
2008 |
|
rs1800067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of one or two XPF/ERCC4 minor alleles at R415Q had decreased risk of pancreatic adenocarcinoma compared with those who had two major alleles [odds ratio (OR), 0.59; 95% confidence interval (95% CI), 0.40-0.85].
|
18544627 |
2008 |
|
rs750040814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of one or two XPF/ERCC4 minor alleles at R415Q had decreased risk of pancreatic adenocarcinoma compared with those who had two major alleles [odds ratio (OR), 0.59; 95% confidence interval (95% CI), 0.40-0.85].
|
18544627 |
2008 |
|
rs1444669684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
|
17349581 |
2007 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although hemochromatosis is associated with pancreatic pathology, the p.C282Y and p.H63D variants do not play a significant role in the pathogenesis of chronic pancreatitis or pancreatic adenocarcinoma.
|
17666895 |
2007 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although hemochromatosis is associated with pancreatic pathology, the p.C282Y and p.H63D variants do not play a significant role in the pathogenesis of chronic pancreatitis or pancreatic adenocarcinoma.
|
17666895 |
2007 |
|
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
|
17349581 |
2007 |
|
rs1370376642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous genes were identified as being differentially expressed, some of which have been previously implicated in pancreatic adenocarcinoma (S100P, S100A4, prostate stem cell antigen, lipocalin 2, claudins 3 and 4, trefoil factors 1 and 2) as well as several novel genes.
|
15305381 |
2004 |
|
rs17107315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the N34S polymorphism of SPINK1 and the 5T and DF508 CFTR polymorphisms do not predispose to the development of pancreatic adenocarcinoma.
|
14688470 |
2004 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.
|
12183419 |
2002 |