Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics. 28468845

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. 28099630

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our results do not support that the common genetic risk variants in rs6265 and rs1006737 are associated with cognitive dysfunction. 27221213

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia. 26603624

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer. 26289590

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia. 26603624

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This study investigated the effects of BDNF Val66Met polymorphism on functional magnetic resonance imaging (fMRI) during n-back WM tasks in healthy middle-aged adults.A total of 110 participants without subjective or objective cognitive impairment underwent BDNF genotyping. 26496261

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study investigated the effects of BDNF Val66Met polymorphism on functional magnetic resonance imaging (fMRI) during n-back WM tasks in healthy middle-aged adults.A total of 110 participants without subjective or objective cognitive impairment underwent BDNF genotyping. 26496261

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role. 24275008

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease. 24394906

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. 24862657

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. 24660789

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role. 24275008

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. 24660789

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease. 24394906

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. 24862657

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. 23769397

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. 23769397

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression. 22739363

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We designed this study to determine if tHcy is causally related to cognitive impairment in later life by investigating its association with high tHcy and the MTHFR-C677T polymorphism. 21358708

2012

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction. 22396415

2012