|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conclude that the A allele of rs1447295 is associated with a higher risk of prostate cancer regardless of tumor aggressiveness, suggesting that such a variant, or a variant in linkage disequilibrium with it, plays a role early in prostate carcinogenesis.
|
17372260 |
2007 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
|
17401363 |
2007 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
|
17401366 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC.
|
17409399 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737.
|
17416775 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified multiple SNPs in a 50-kb region (referred to as locus 1) that are in linkage disequilibrium with a previously reported risk-associated SNP at 8q24, rs1447295, but were more strongly associated with prostate cancer risk in our study population.
|
17925536 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
|
19428064 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
|
19767754 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02).
|
19900942 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Analysis of the cumulative risk of rs1447295, a confirmed risk variant, and one of these markers showed that compared to men who do not have any of these risk variants, men who carry any combination of 1 or 2 risk genotypes have a gradually increased prostate cancer risk (P for trend <0.001).
|
19908238 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere.
|
19952762 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Allele -8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer.
|
20700145 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
• The frequencies of three CaP risk alleles (rs1447295 [8q24], P= 0.004; rs1571801 [9q33.2], P= 0.03; rs11228565 [11q13], P= 0.02) were significantly higher in men with 'unfavourable' pathological characteristics.
|
22077888 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For northern Chinese men rs16901966, rs1447295, rs11986220 and rs10090154 at 8q24 (region 1, region 2) are associated with prostate cancer and prostate cancer related clinical covariates.
|
22099997 |
2012 |