|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Allele -8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer.
|
20700145 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Analysis of the cumulative risk of rs1447295, a confirmed risk variant, and one of these markers showed that compared to men who do not have any of these risk variants, men who carry any combination of 1 or 2 risk genotypes have a gradually increased prostate cancer risk (P for trend <0.001).
|
19908238 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Evaluating genetic risk for prostate cancer among Japanese and Latinos.
|
22923026 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For northern Chinese men rs16901966, rs1447295, rs11986220 and rs10090154 at 8q24 (region 1, region 2) are associated with prostate cancer and prostate cancer related clinical covariates.
|
22099997 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
|
19767754 |
2009 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
|
17401366 |
2007 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
|
17401363 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
|
23555315 |
2013 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere.
|
19952762 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer.
|
30061842 |
2018 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.
|
26159557 |
2015 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737.
|
17416775 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele at SNP rs1447295 was associated with the incidence of prostate cancer.
|
22583965 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates.
|
24377597 |
2014 |