|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conclude that the A allele of rs1447295 is associated with a higher risk of prostate cancer regardless of tumor aggressiveness, suggesting that such a variant, or a variant in linkage disequilibrium with it, plays a role early in prostate carcinogenesis.
|
17372260 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Evaluating genetic risk for prostate cancer among Japanese and Latinos.
|
22923026 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.
|
28978014 |
2017 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC.
|
17409399 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Allele -8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer.
|
20700145 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified multiple SNPs in a 50-kb region (referred to as locus 1) that are in linkage disequilibrium with a previously reported risk-associated SNP at 8q24, rs1447295, but were more strongly associated with prostate cancer risk in our study population.
|
17925536 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
• The frequencies of three CaP risk alleles (rs1447295 [8q24], P= 0.004; rs1571801 [9q33.2], P= 0.03; rs11228565 [11q13], P= 0.02) were significantly higher in men with 'unfavourable' pathological characteristics.
|
22077888 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Analysis of the cumulative risk of rs1447295, a confirmed risk variant, and one of these markers showed that compared to men who do not have any of these risk variants, men who carry any combination of 1 or 2 risk genotypes have a gradually increased prostate cancer risk (P for trend <0.001).
|
19908238 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
|
23555315 |
2013 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates.
|
24377597 |
2014 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP.
|
23628314 |
2014 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.
|
26159557 |
2015 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For northern Chinese men rs16901966, rs1447295, rs11986220 and rs10090154 at 8q24 (region 1, region 2) are associated with prostate cancer and prostate cancer related clinical covariates.
|
22099997 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737.
|
17416775 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02).
|
19900942 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere.
|
19952762 |
2010 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |