|
rs11669576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs1401663578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs1799752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004).
|
27639288 |
2017 |
|
rs1800764
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs2281983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigates whether a common polymorphism in the PITX3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in PD and whether it affects dopamine transporter (DAT) uptake.
|
28991698 |
2017 |
|
rs2337506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRFAM7A-2-bp deletion or CHRNA7 SNPs (rs1514246, rs2337506, rs8027814) seem protective factors in different forms of dementia including AD.
|
26424395 |
2017 |
|
rs2695121
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs5186
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004).
|
27639288 |
2017 |
|
rs5930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121.
|
28099631 |
2017 |
|
rs63749835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.
|
28532645 |
2017 |
|
rs63750004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants from five families with early-onset autosomal-dominant mutations (Swedish and Arctic APP, PSEN1 M146V, H163Y, and I143T) included 35 carriers (28 without dementia and 7 with) and 44 non-carriers.
|
28079014 |
2017 |
|
rs763872192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, these results suggest a sex dependent neuroprotective effect of LFPD in P301L-tg mice, suggesting that lifestyle intervention strategies may be clinically relevant for delaying the onset of cognitive impairment and dementia, especially in females.
|
28456717 |
2017 |
|
rs767543900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, cerebrospinal fluid (CSF) levels of tau, p-tau and amyloid Aβ42 were measured in these patients and in an additional cohort of 5 symptomatic and 2 asymptomatic p.A53T carriers without an initial manifestation of dementia.
|
28012952 |
2017 |
|
rs773819452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gerstmann-Sträussler-Scheinker syndrome caused by the P102L mutation in the prion protein gene (GSS102) is usually characterized by the onset of slowly progressive cerebellar ataxia, with dementia occurring much later.
|
28131204 |
2017 |
|
rs8027814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRFAM7A-2-bp deletion or CHRNA7 SNPs (rs1514246, rs2337506, rs8027814) seem protective factors in different forms of dementia including AD.
|
26424395 |
2017 |
|
rs901115236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our finding revealed the clinical manifestations of variant p.A35D (c.104C>A) in a LOAD case and indicated that CHCHD10 mutation was presented in different types of dementia.
|
27578015 |
2017 |
|
rs104893941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Amongst the 6 family members analyzed, the p.P392L SQSTM1 mutation segregated as expected with PDB, whereas the C9orf72 expansion segregated with frontal cognitive impairment or dementia in all but one carrier.
|
26839080 |
2016 |
|
rs12976445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed that rs12976445 is significantly associated with the risk of dementia after ischemic stroke.
|
27106952 |
2016 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although subjects with rs2228145 carrier had significantly higher IL-6 levels, a significant association between r</span>s2228145 and dementia was not observed.
|
26725994 |
2016 |
|
rs3093059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a cohort of Japanese participants with vascular risk factors in an observational study from 2001, the association between baseline IL-6, CRP levels, gene variants [interleukin-6 receptor (IL-6R), rs2228145; IL-6, rs2097677; CRP, rs3093059] and incident all-cause dementia was evaluated.
|
26725994 |
2016 |
|
rs74315407
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This report suggests to consider the diagnosis of V210I genetic CJD in patients presenting with the Heidenhain form of CJD and highlights the importance of genetic testing in all patients with isolated visual manifestations at onset followed by progressive neurological signs and dementia.
|
26268049 |
2016 |
|
rs104894002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations of Q33X, Y38C and T66M cause Nasu-Hakola disease (NHD) which is characterized by early onset of dementia and bone cysts.
|
25615530 |
2015 |
|
rs112451138
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we report three novel PSEN1 mutations: Ile238_Lys239insIle, Ala246Pro and Ala164Val from patients who manifested in their twenties, forties and seventies, respectively, with variant clinical presentations of dementia.
|
26350633 |
2015 |
|
rs1341026713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutation p.M233L was associated with prominent very early onset, rapidly progressive dementia, and neurologic symptoms, whereas p.R352C was associated with a progressive dementia, psychiatric syndrome, and chronic disease course.
|
25595498 |
2015 |