rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders.
|
30929061 |
2020 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
|
30078664 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
|
30078664 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism may confer risk for mood disorders in females through effects on amygdala-cortical connectivity during adolescence, coinciding with a period in the lifespan when onset of depression often occurs, more commonly in females.
|
28387866 |
2018 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD).
|
30347685 |
2018 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD).
|
30347685 |
2018 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism may confer risk for mood disorders in females through effects on amygdala-cortical connectivity during adolescence, coinciding with a period in the lifespan when onset of depression often occurs, more commonly in females.
|
28387866 |
2018 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach.
|
28427565 |
2017 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders.
|
28926000 |
2017 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach.
|
28427565 |
2017 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders.
|
28926000 |
2017 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset.
|
27697135 |
2016 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, previous genetic association studies of Val66Met polymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statistical association or ancestry-specific effects.
|
27236043 |
2016 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, previous genetic association studies of Val66Met polymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statistical association or ancestry-specific effects.
|
27236043 |
2016 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset.
|
27697135 |
2016 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF polymorphism, val66met, has also been implicated in mood disorders.
|
24398043 |
2014 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder.
|
24112874 |
2014 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191).
|
24944871 |
2014 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder.
|
24112874 |
2014 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF polymorphism, val66met, has also been implicated in mood disorders.
|
24398043 |
2014 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders.
|
23823988 |
2013 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders.
|
23823988 |
2013 |