|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conclude that the A allele of rs1447295 is associated with a higher risk of prostate cancer regardless of tumor aggressiveness, suggesting that such a variant, or a variant in linkage disequilibrium with it, plays a role early in prostate carcinogenesis.
|
17372260 |
2007 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
|
17401363 |
2007 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78).
|
17401363 |
2007 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78).
|
17401363 |
2007 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
|
17401366 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC.
|
17409399 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737.
|
17416775 |
2007 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified multiple SNPs in a 50-kb region (referred to as locus 1) that are in linkage disequilibrium with a previously reported risk-associated SNP at 8q24, rs1447295, but were more strongly associated with prostate cancer risk in our study population.
|
17925536 |
2007 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Analysis of the National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer association study database alone and in combination with our data provided further evidence for this second prostate cancer risk locus; in the combined analysis, the allele frequencies for rs6983267 differed statistically significantly between case patients and control subjects (P = 1.61 x 10(-9)).
|
17925536 |
2007 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs7000448
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association.
|
18360876 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further studies are required to confirm whether the adjacent breast cancer-associated variant rs13281615 may be inversely associated with prostate cancer risk.
|
18625567 |
2009 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21).
|
18726982 |
2008 |
|
rs7841264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the association between prostate cancer risk and the CC genotype of rs7841264, which marked the recombination hotspot at 8q24, was confined to patients with the highest Gleason score (odds ratio, 2.15; 95% confidence interval, 1.27-3.64; P=0.004).
|
18765558 |
2008 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker.
|
19047180 |
2008 |