|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
|
31562322 |
2019 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
|
31562322 |
2019 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer.
|
30061842 |
2018 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.
|
28978014 |
2017 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, though no association was observed between the rs</span>6983267 polymorphism and risk of prostate cancer, subgroup analysis according to ethnicity showed a significant association between the rs6983267 polymorphism and risk of prostate cancer among white European men [recessive model: GG vs TG + TT, OR=1.21, (95% CI: 1.03, 1.42), P=0.02].
|
27009866 |
2016 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.
|
26159557 |
2015 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
|
26034056 |
2015 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory.
|
26159557 |
2015 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Similarly, in a subgroup analysis of European and Asian descent, our results revealed that there are associations between rs6983267 T/G polymorphism and PCa susceptibility with the dominant model (GG vs GT+TT), recessive model (GG+GT vs TT), and homozygote comparison (GG vs TT).
|
26782586 |
2015 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates.
|
24377597 |
2014 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP.
|
23628314 |
2014 |
|
rs1447295
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The polymorphism rs6983267 from region 3 of the chromosome 8q24 appears to be a prominent risk factor for PCa and a biomarker for cancer aggressiveness in the group of patients who presented higher levels of PSA at the time of diagnosis.
|
24224612 |
2014 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01).
|
25315430 |
2014 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Significant associations were observed for rs4430796 TT with Gleason scores of ≥ 7 (OR = 1.76, 95% CI = 1.14-2.73) and prostate-specific antigen (PSA) levels of ≥ 10 ng/ml at diagnosis (OR = 1.63, 95% CI = 1.01-2.63), as well as for rs6983267 GG with stage 3-4 CaPs (OR = 1.91, 95% CI = 1.01-3.61).
|
22561070 |
2013 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
• The frequencies of three CaP risk alleles (rs1447295 [8q24], P= 0.004; rs1571801 [9q33.2], P= 0.03; rs11228565 [11q13], P= 0.02) were significantly higher in men with 'unfavourable' pathological characteristics.
|
22077888 |
2012 |
|
rs1447295
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele at SNP rs1447295 was associated with the incidence of prostate cancer.
|
22583965 |
2012 |